King's College London

Research portal

Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study

Research output: Contribution to journalArticle

Standard

Associations between maternal prenatal cortisol and fetal growth are specific to infant sex : findings from the Wirral Child Health and Development Study. / Braithwaite, E. C.; Hill, J.; Pickles, A.; Glover, V.; O’Donnell, K.; Sharp, H.

In: Journal of Developmental Origins of Health and Disease, 08.2018, p. 425-431.

Research output: Contribution to journalArticle

Harvard

Braithwaite, EC, Hill, J, Pickles, A, Glover, V, O’Donnell, K & Sharp, H 2018, 'Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study', Journal of Developmental Origins of Health and Disease, pp. 425-431. https://doi.org/10.1017/S2040174418000181

APA

Braithwaite, E. C., Hill, J., Pickles, A., Glover, V., O’Donnell, K., & Sharp, H. (2018). Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study. Journal of Developmental Origins of Health and Disease, 425-431. https://doi.org/10.1017/S2040174418000181

Vancouver

Braithwaite EC, Hill J, Pickles A, Glover V, O’Donnell K, Sharp H. Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study. Journal of Developmental Origins of Health and Disease. 2018 Aug;425-431. https://doi.org/10.1017/S2040174418000181

Author

Braithwaite, E. C. ; Hill, J. ; Pickles, A. ; Glover, V. ; O’Donnell, K. ; Sharp, H. / Associations between maternal prenatal cortisol and fetal growth are specific to infant sex : findings from the Wirral Child Health and Development Study. In: Journal of Developmental Origins of Health and Disease. 2018 ; pp. 425-431.

Bibtex Download

@article{de2ed495b68b4c21b4817a823aaccdd4,
title = "Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study",
abstract = "Recent findings highlight that there are prenatal risks for affective disorders that are mediated by glucocorticoid mechanisms, and may be specific to females. There is also evidence of sex differences in prenatal programming mechanisms and developmental psychopathology, whereby effects are in opposite directions in males and females. As birth weight is a risk for affective disorders, we sought to investigate whether maternal prenatal cortisol may have sex-specific effects on fetal growth. Participants were 241 mothers selected from the Wirral Child Health and Development Study (WCHADS) cohort (n=1233) using a psychosocial risk stratifier, so that responses could be weighted back to the general population. Mothers provided saliva samples, which were assayed for cortisol, at home over 2 days at 32 weeks gestation (on waking, 30-min post-waking and during the evening). Measures of infant birth weight (corrected for gestational age) were taken from hospital records. General population estimates of associations between variables were obtained using inverse probability weights. Maternal log of the area under the curve cortisol predicted infant birth weight in a sex-dependent manner (interaction term P=0.029). There was a positive and statistically significant association between prenatal cortisol in males, and a negative association in females that was not statistically significant. A sex interaction in the same direction was evident when using the waking (P=0.015), and 30-min post-waking (P=0.013) cortisol, but not the evening measure. There was no interaction between prenatal cortisol and sex to predict gestational age. Our findings add to an emerging literature that suggests that there may be sex-specific mechanisms that underpin fetal programming.",
keywords = "birth weight, fetal programming, glucocorticoids, HPA axis, prenatal stress",
author = "Braithwaite, {E. C.} and J. Hill and A. Pickles and V. Glover and K. O{\textquoteright}Donnell and H. Sharp",
year = "2018",
month = aug,
doi = "10.1017/S2040174418000181",
language = "English",
pages = "425--431",
journal = "Journal of Developmental Origins of Health and Disease",
issn = "2040-1744",
publisher = "Cambridge University Press",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Associations between maternal prenatal cortisol and fetal growth are specific to infant sex

T2 - findings from the Wirral Child Health and Development Study

AU - Braithwaite, E. C.

AU - Hill, J.

AU - Pickles, A.

AU - Glover, V.

AU - O’Donnell, K.

AU - Sharp, H.

PY - 2018/8

Y1 - 2018/8

N2 - Recent findings highlight that there are prenatal risks for affective disorders that are mediated by glucocorticoid mechanisms, and may be specific to females. There is also evidence of sex differences in prenatal programming mechanisms and developmental psychopathology, whereby effects are in opposite directions in males and females. As birth weight is a risk for affective disorders, we sought to investigate whether maternal prenatal cortisol may have sex-specific effects on fetal growth. Participants were 241 mothers selected from the Wirral Child Health and Development Study (WCHADS) cohort (n=1233) using a psychosocial risk stratifier, so that responses could be weighted back to the general population. Mothers provided saliva samples, which were assayed for cortisol, at home over 2 days at 32 weeks gestation (on waking, 30-min post-waking and during the evening). Measures of infant birth weight (corrected for gestational age) were taken from hospital records. General population estimates of associations between variables were obtained using inverse probability weights. Maternal log of the area under the curve cortisol predicted infant birth weight in a sex-dependent manner (interaction term P=0.029). There was a positive and statistically significant association between prenatal cortisol in males, and a negative association in females that was not statistically significant. A sex interaction in the same direction was evident when using the waking (P=0.015), and 30-min post-waking (P=0.013) cortisol, but not the evening measure. There was no interaction between prenatal cortisol and sex to predict gestational age. Our findings add to an emerging literature that suggests that there may be sex-specific mechanisms that underpin fetal programming.

AB - Recent findings highlight that there are prenatal risks for affective disorders that are mediated by glucocorticoid mechanisms, and may be specific to females. There is also evidence of sex differences in prenatal programming mechanisms and developmental psychopathology, whereby effects are in opposite directions in males and females. As birth weight is a risk for affective disorders, we sought to investigate whether maternal prenatal cortisol may have sex-specific effects on fetal growth. Participants were 241 mothers selected from the Wirral Child Health and Development Study (WCHADS) cohort (n=1233) using a psychosocial risk stratifier, so that responses could be weighted back to the general population. Mothers provided saliva samples, which were assayed for cortisol, at home over 2 days at 32 weeks gestation (on waking, 30-min post-waking and during the evening). Measures of infant birth weight (corrected for gestational age) were taken from hospital records. General population estimates of associations between variables were obtained using inverse probability weights. Maternal log of the area under the curve cortisol predicted infant birth weight in a sex-dependent manner (interaction term P=0.029). There was a positive and statistically significant association between prenatal cortisol in males, and a negative association in females that was not statistically significant. A sex interaction in the same direction was evident when using the waking (P=0.015), and 30-min post-waking (P=0.013) cortisol, but not the evening measure. There was no interaction between prenatal cortisol and sex to predict gestational age. Our findings add to an emerging literature that suggests that there may be sex-specific mechanisms that underpin fetal programming.

KW - birth weight

KW - fetal programming

KW - glucocorticoids

KW - HPA axis

KW - prenatal stress

UR - http://www.scopus.com/inward/record.url?scp=85045078712&partnerID=8YFLogxK

U2 - 10.1017/S2040174418000181

DO - 10.1017/S2040174418000181

M3 - Article

AN - SCOPUS:85045078712

SP - 425

EP - 431

JO - Journal of Developmental Origins of Health and Disease

JF - Journal of Developmental Origins of Health and Disease

SN - 2040-1744

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454