Associations between Periodontitis, COVID-19, and Cardiometabolic Complications: Molecular Mechanisms and Clinical Evidence

Giuseppe Mainas, Luigi Nibali, Mark Ide, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Macieji Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Manfredi Rizzo*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)
56 Downloads (Pure)


Periodontitis is a microbially driven, host-mediated disease that leads to loss of periodontal attachment and resorption of bone. It is associated with the elevation of systemic inflammatory markers and with the presence of systemic comorbidities. Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although the majority of patients have mild symptoms, others experience important complications that can lead to death. After the spread of the COVID-19 pandemic, several investigations demonstrating the possible relationship between periodontitis and COVID-19 have been reported. In addition, both periodontal disease and COVID-19 seem to provoke and/or impair several cardiometabolic complications such as cardiovascular disease, type 2 diabetes, metabolic syndrome, dyslipidemia, insulin resistance, obesity, non-alcoholic fatty liver disease, and neurological and neuropsychiatric complications. Therefore, due to the increasing number of investigations focusing on the periodontitisCOVID-19 relationship and considering the severe complications that such an association might cause, this review aims to summarize all existing emerging evidence regarding the link between the periodontitis-COVID-19 axis and consequent cardiometabolic impairments
Original languageEnglish
Article number13010040
Pages (from-to)40
Number of pages17
Publication statusPublished - 26 Dec 2022


  • periodontitis
  • periodontal diseases
  • COVID-19
  • SARS-CoV-2
  • comorbidity
  • risk
  • non-communicable diseases


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