TY - JOUR
T1 - Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjögren's syndrome among 1,726 registry participants
AU - Daniels, Troy E.
AU - Cox, Darren
AU - Shiboski, Caroline H.
AU - Schiodt, Morten
AU - Wu, Ava
AU - Lanfranchi, Hector
AU - Umehara, Hisanori
AU - Zhao, Yan
AU - Challacombe, Stephen
AU - Lam, Mi Y.
AU - De Souza, Yvonne
AU - Schiodt, Julie
AU - Holm, Helena
AU - Bisio, Patricia A. M.
AU - Gandolfo, Mariana S.
AU - Sawaki, Toshioki
AU - Li, Mengtao
AU - Zhang, Wen
AU - Varghese-Jacob, Beni
AU - Ibsen, Per
AU - Keszler, Alicia
AU - Kurose, Nozomu
AU - Nojima, Takayuki
AU - Odell, Edward
AU - Criswell, Lindsey A.
AU - Jordan, Richard
AU - Greenspan, John S.
PY - 2011/7
Y1 - 2011/7
N2 - Objective. To examine associations between labial salivary gland (LSG) histopathology and other phenotypic features of Sjogren's syndrome (SS).
Methods. The database of the Sjogren's International Collaborative Clinical Alliance (SICCA), a registry of patients with symptoms of possible SS as well as those with obvious disease, was used for the present study. LSG biopsy specimens from SICCA participants were subjected to protocol-directed histopathologic assessments. Among the 1,726 LSG specimens exhibiting any pattern of sialadenitis, we compared biopsy diagnoses against concurrent salivary, ocular, and serologic features.
Results. LSG specimens included 61% with focal lymphocytic sialadenitis (FLS; 69% of which had focus scores of >= 1. per 4 mm(2)) and 37% with nonspecific or sclerosing chronic sialadenitis (NS/SCS). Focus scores of >= 1 were strongly associated with serum anti-SSA/SSB positivity, rheumatoid factor, and the ocular component of SS, but not with symptoms of dry mouth or dry eyes. Those with positive anti-SSA/SSB were 9 times (95% confidence interval [95% CI] 7.4-11.9) more likely to have a focus score of >= 1 than were those without anti-SSA/SSB, and those with an unstimulated whole salivary flow rate of = 1 than were those with a higher flow rate, after controlling for other phenotypic features of SS.
Conclusion. Distinguishing FLS from NS/SCS is essential in assessing LSG biopsies, before determining focus score. A diagnosis of FLS with a focus score of >= 1 per 4 mm(2), as compared to FLS with a focus score of
AB - Objective. To examine associations between labial salivary gland (LSG) histopathology and other phenotypic features of Sjogren's syndrome (SS).
Methods. The database of the Sjogren's International Collaborative Clinical Alliance (SICCA), a registry of patients with symptoms of possible SS as well as those with obvious disease, was used for the present study. LSG biopsy specimens from SICCA participants were subjected to protocol-directed histopathologic assessments. Among the 1,726 LSG specimens exhibiting any pattern of sialadenitis, we compared biopsy diagnoses against concurrent salivary, ocular, and serologic features.
Results. LSG specimens included 61% with focal lymphocytic sialadenitis (FLS; 69% of which had focus scores of >= 1. per 4 mm(2)) and 37% with nonspecific or sclerosing chronic sialadenitis (NS/SCS). Focus scores of >= 1 were strongly associated with serum anti-SSA/SSB positivity, rheumatoid factor, and the ocular component of SS, but not with symptoms of dry mouth or dry eyes. Those with positive anti-SSA/SSB were 9 times (95% confidence interval [95% CI] 7.4-11.9) more likely to have a focus score of >= 1 than were those without anti-SSA/SSB, and those with an unstimulated whole salivary flow rate of = 1 than were those with a higher flow rate, after controlling for other phenotypic features of SS.
Conclusion. Distinguishing FLS from NS/SCS is essential in assessing LSG biopsies, before determining focus score. A diagnosis of FLS with a focus score of >= 1 per 4 mm(2), as compared to FLS with a focus score of
U2 - 10.1002/art.30381
DO - 10.1002/art.30381
M3 - Article
SN - 1529-0131
VL - 63
SP - 2021
EP - 2030
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 7
ER -