Abstract
We sought to test the hypothesis that the rs1344706 A allele will be associated with worse clinical outcome in first-episode
psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record
case register at the South London and Maudsley NHS Foundation Trust—a large provider of secondary mental-health care. A
sample of 291 patients, who presented with a first psychotic episode (ICD10 diagnoses F20–29 or F30–33) and in whom the
rs1344706 genotype had been assayed, were followed to examine the duration of mental-health in-patient care during the 2 years
following first service contact, as a primary outcome. Secondary outcome measures were whether or not an in-patient episode
occurred and the number of in-patient episodes during this period. A strong association was found between the number of
rs1344706 A alleles and the cumulative duration of mental-health in-patient stay over the 2 years since initial presentation. In the
84.2% who experienced an in-patient episode during this period, the mean duration of admission was an additional 38 days for
each A allele increment. Therefore, in addition to its potential role as a risk factor for psychosis, the ZNF804A rs1344706 A allele is
associated with worse clinical outcome.
psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record
case register at the South London and Maudsley NHS Foundation Trust—a large provider of secondary mental-health care. A
sample of 291 patients, who presented with a first psychotic episode (ICD10 diagnoses F20–29 or F30–33) and in whom the
rs1344706 genotype had been assayed, were followed to examine the duration of mental-health in-patient care during the 2 years
following first service contact, as a primary outcome. Secondary outcome measures were whether or not an in-patient episode
occurred and the number of in-patient episodes during this period. A strong association was found between the number of
rs1344706 A alleles and the cumulative duration of mental-health in-patient stay over the 2 years since initial presentation. In the
84.2% who experienced an in-patient episode during this period, the mean duration of admission was an additional 38 days for
each A allele increment. Therefore, in addition to its potential role as a risk factor for psychosis, the ZNF804A rs1344706 A allele is
associated with worse clinical outcome.
| Original language | English |
|---|---|
| Article number | e698 |
| Journal | Translational psychiatry |
| DOIs | |
| Publication status | Published - 15 Dec 2015 |