Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis

Anu Wickramasinghe, Alexander David Tulloch, Richard Derek Hayes, CK Chang, Matthew Broadbent, Marta DiForti, Robin MacGregor Murray, Conrad Osamede Iyegbe, Robert James Stewart

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Abstract

We sought to test the hypothesis that the rs1344706 A allele will be associated with worse clinical outcome in first-episode
psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record
case register at the South London and Maudsley NHS Foundation Trust—a large provider of secondary mental-health care. A
sample of 291 patients, who presented with a first psychotic episode (ICD10 diagnoses F20–29 or F30–33) and in whom the
rs1344706 genotype had been assayed, were followed to examine the duration of mental-health in-patient care during the 2 years
following first service contact, as a primary outcome. Secondary outcome measures were whether or not an in-patient episode
occurred and the number of in-patient episodes during this period. A strong association was found between the number of
rs1344706 A alleles and the cumulative duration of mental-health in-patient stay over the 2 years since initial presentation. In the
84.2% who experienced an in-patient episode during this period, the mean duration of admission was an additional 38 days for
each A allele increment. Therefore, in addition to its potential role as a risk factor for psychosis, the ZNF804A rs1344706 A allele is
associated with worse clinical outcome.
Original languageEnglish
Article numbere698
JournalTranslational psychiatry
DOIs
Publication statusPublished - 15 Dec 2015

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