Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: A case-control and meta-analysis study

TY - JOUR

T1 - Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: A case-control and meta-analysis study

AU - Onnie, C M

AU - Fisher, S A

AU - Pattni, R

AU - Sanderson, J

AU - Forbes, A

AU - Lewis, C M

AU - Mathew, C G

PY - 2006/4

Y1 - 2006/4

N2 - Background: Allelic variants of the ATP-binding cassette, subfamily B member 1 (ABCB1), also known as the multidrug resistance gene (MDR1) that encodes the membrane-bound efflux transporter P-glycoprotein 170 (PGP-170), have been associated with inflammatory bowel disease but with conflicting results Methods: The present study examined the association of ABCB1 C3435T and G2677T/A in a large British case-control cohort of 828 Crohn's disease, 580 ulcerative colitis (UC) cases, and 285 healthy controls. The effect of these variants was further examined with respect to phenotypic and epidemiological characteristics. A meta-analysis was carried Out Of Our results and those from 8 previously published association studies of file C3435T variant in inflammatory bowel disease. Results: The 2677T allele was significantly increased in British UC cases compared with controls (45.2% vs. 39.6%; P = 0.034). In particular, the TT genotype was significantly associated with severe UC (odds ratio [OR] 1.90; 95% Cl 1.01-3.55) and the use of steroids in UC (OR 1.77; 95% Cl 1.08-2.88). No significant association was seen with C3435T and UC, Crohn's disease, or any clinical Subgroup. A meta-analysis of 9 association studies of C3435T showed a significant association of the 3435T allele with UC (OR 1.12; 95% Cl 1.02-1.23; P=0.013) but not with CD. Conclusions: These results indicate that ABCB1 sequence variants are associated with a small increase in the risk of developing UC and may influence disease behavior

AB - Background: Allelic variants of the ATP-binding cassette, subfamily B member 1 (ABCB1), also known as the multidrug resistance gene (MDR1) that encodes the membrane-bound efflux transporter P-glycoprotein 170 (PGP-170), have been associated with inflammatory bowel disease but with conflicting results Methods: The present study examined the association of ABCB1 C3435T and G2677T/A in a large British case-control cohort of 828 Crohn's disease, 580 ulcerative colitis (UC) cases, and 285 healthy controls. The effect of these variants was further examined with respect to phenotypic and epidemiological characteristics. A meta-analysis was carried Out Of Our results and those from 8 previously published association studies of file C3435T variant in inflammatory bowel disease. Results: The 2677T allele was significantly increased in British UC cases compared with controls (45.2% vs. 39.6%; P = 0.034). In particular, the TT genotype was significantly associated with severe UC (odds ratio [OR] 1.90; 95% Cl 1.01-3.55) and the use of steroids in UC (OR 1.77; 95% Cl 1.08-2.88). No significant association was seen with C3435T and UC, Crohn's disease, or any clinical Subgroup. A meta-analysis of 9 association studies of C3435T showed a significant association of the 3435T allele with UC (OR 1.12; 95% Cl 1.02-1.23; P=0.013) but not with CD. Conclusions: These results indicate that ABCB1 sequence variants are associated with a small increase in the risk of developing UC and may influence disease behavior

U2 - 10.1097/01.MIB.0000209791.98866.ba

DO - 10.1097/01.MIB.0000209791.98866.ba

M3 - Article

VL - 12

SP - 263

EP - 271

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

IS - 4

ER -