Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort

Natalia Ballardini; Michael S. Kramer; Emily Oken; Alexander John Henderson; Natalia Bogdanovich; Mourad Dahhou; Rita Patel; Jennifer Thompson; Konstantin Vilchuck; Seungmi Yang; Richard M. Martin; Carsten Flohr

doi:10.1111/cea.13417

Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort

Natalia Ballardini^*, Michael S. Kramer, Emily Oken, Alexander John Henderson, Natalia Bogdanovich, Mourad Dahhou, Rita Patel, Jennifer Thompson, Konstantin Vilchuck, Seungmi Yang, Richard M. Martin, Carsten Flohr

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Background: Conflicting findings from studies evaluating associations of allergic disease with child behaviour require longitudinal studies to resolve. Objective: To estimate the magnitude of associations of atopic dermatitis (AD) in infancy, and symptoms of asthma and AD at 6.5 years, with child behaviour at 6.5 years. Methods: Secondary cohort analysis of the Promotion of Breastfeeding Intervention Trial (PROBIT). PROBIT enrolled 17 046 infants at birth and followed them up at 6.5 years (n = 13 889). Study paediatricians collected data on infantile AD at repeated follow-up examinations during the first year of life. At 6.5 years, paediatricians performed skin prick tests and parents reported asthma and AD symptoms during the prior year. In addition, parents and teachers completed the Strength and Difficulties Questionnaire, which includes scales on hyperactivity/inattention, emotional problems, conduct problems, peer problems and prosocial behaviours. Results: Physician-diagnosed AD in the first year of life was not associated with increased risk for behavioural problems at 6.5 years. Emotional problems at 6.5 years were more common among children with AD symptoms (OR: 2.24, 95% CI: 1.62-3.12) and asthma symptoms (OR: 1.45; 95% CI: 1.07-1.96) during the past year at 6.5 years and ORs for children with symptoms of more severe AD and asthma were also higher. AD in the past year was also associated with probable hyperactivity/inattention disorder at 6.5 years (OR: 2.05; 95% CI: 1.09-3.84). Other subscales of the SDQ were not related to asthma or AD symptoms during the past year. Conclusions and clinical relevance: Children with AD symptoms were at higher risk for concomitant hyperactivity/inattention and emotional disorder, and children with asthma symptoms were at higher risk of having concomitant emotional problems. However, AD during infancy did not predict childhood behaviours.

Original language	English
Pages (from-to)	1235-1244
Number of pages	10
Journal	Clinical and Experimental Allergy
Volume	49
Issue number	9
DOIs	https://doi.org/10.1111/cea.13417
Publication status	Published - 1 Sept 2019

Keywords

asthma
atopic dermatitis
behaviour,dermatology
epidemiology
paediatrics
PROBIT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/cea.13417

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@article{4c844fd02ca84762a117bb3b17aef755,

title = "Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort",

abstract = "Background: Conflicting findings from studies evaluating associations of allergic disease with child behaviour require longitudinal studies to resolve. Objective: To estimate the magnitude of associations of atopic dermatitis (AD) in infancy, and symptoms of asthma and AD at 6.5 years, with child behaviour at 6.5 years. Methods: Secondary cohort analysis of the Promotion of Breastfeeding Intervention Trial (PROBIT). PROBIT enrolled 17 046 infants at birth and followed them up at 6.5 years (n = 13 889). Study paediatricians collected data on infantile AD at repeated follow-up examinations during the first year of life. At 6.5 years, paediatricians performed skin prick tests and parents reported asthma and AD symptoms during the prior year. In addition, parents and teachers completed the Strength and Difficulties Questionnaire, which includes scales on hyperactivity/inattention, emotional problems, conduct problems, peer problems and prosocial behaviours. Results: Physician-diagnosed AD in the first year of life was not associated with increased risk for behavioural problems at 6.5 years. Emotional problems at 6.5 years were more common among children with AD symptoms (OR: 2.24, 95% CI: 1.62-3.12) and asthma symptoms (OR: 1.45; 95% CI: 1.07-1.96) during the past year at 6.5 years and ORs for children with symptoms of more severe AD and asthma were also higher. AD in the past year was also associated with probable hyperactivity/inattention disorder at 6.5 years (OR: 2.05; 95% CI: 1.09-3.84). Other subscales of the SDQ were not related to asthma or AD symptoms during the past year. Conclusions and clinical relevance: Children with AD symptoms were at higher risk for concomitant hyperactivity/inattention and emotional disorder, and children with asthma symptoms were at higher risk of having concomitant emotional problems. However, AD during infancy did not predict childhood behaviours.",

keywords = "asthma, atopic dermatitis, behaviour,dermatology, epidemiology, paediatrics, PROBIT",

author = "Natalia Ballardini and Kramer, {Michael S.} and Emily Oken and Henderson, {Alexander John} and Natalia Bogdanovich and Mourad Dahhou and Rita Patel and Jennifer Thompson and Konstantin Vilchuck and Seungmi Yang and Martin, {Richard M.} and Carsten Flohr",

year = "2019",

month = sep,

day = "1",

doi = "10.1111/cea.13417",

language = "English",

volume = "49",

pages = "1235--1244",

journal = "Clinical and Experimental Allergy",

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TY - JOUR

T1 - Associations of atopic dermatitis and asthma with child behaviour

T2 - Results from the PROBIT cohort

AU - Ballardini, Natalia

AU - Kramer, Michael S.

AU - Oken, Emily

AU - Henderson, Alexander John

AU - Bogdanovich, Natalia

AU - Dahhou, Mourad

AU - Patel, Rita

AU - Thompson, Jennifer

AU - Vilchuck, Konstantin

AU - Yang, Seungmi

AU - Martin, Richard M.

AU - Flohr, Carsten

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Background: Conflicting findings from studies evaluating associations of allergic disease with child behaviour require longitudinal studies to resolve. Objective: To estimate the magnitude of associations of atopic dermatitis (AD) in infancy, and symptoms of asthma and AD at 6.5 years, with child behaviour at 6.5 years. Methods: Secondary cohort analysis of the Promotion of Breastfeeding Intervention Trial (PROBIT). PROBIT enrolled 17 046 infants at birth and followed them up at 6.5 years (n = 13 889). Study paediatricians collected data on infantile AD at repeated follow-up examinations during the first year of life. At 6.5 years, paediatricians performed skin prick tests and parents reported asthma and AD symptoms during the prior year. In addition, parents and teachers completed the Strength and Difficulties Questionnaire, which includes scales on hyperactivity/inattention, emotional problems, conduct problems, peer problems and prosocial behaviours. Results: Physician-diagnosed AD in the first year of life was not associated with increased risk for behavioural problems at 6.5 years. Emotional problems at 6.5 years were more common among children with AD symptoms (OR: 2.24, 95% CI: 1.62-3.12) and asthma symptoms (OR: 1.45; 95% CI: 1.07-1.96) during the past year at 6.5 years and ORs for children with symptoms of more severe AD and asthma were also higher. AD in the past year was also associated with probable hyperactivity/inattention disorder at 6.5 years (OR: 2.05; 95% CI: 1.09-3.84). Other subscales of the SDQ were not related to asthma or AD symptoms during the past year. Conclusions and clinical relevance: Children with AD symptoms were at higher risk for concomitant hyperactivity/inattention and emotional disorder, and children with asthma symptoms were at higher risk of having concomitant emotional problems. However, AD during infancy did not predict childhood behaviours.

AB - Background: Conflicting findings from studies evaluating associations of allergic disease with child behaviour require longitudinal studies to resolve. Objective: To estimate the magnitude of associations of atopic dermatitis (AD) in infancy, and symptoms of asthma and AD at 6.5 years, with child behaviour at 6.5 years. Methods: Secondary cohort analysis of the Promotion of Breastfeeding Intervention Trial (PROBIT). PROBIT enrolled 17 046 infants at birth and followed them up at 6.5 years (n = 13 889). Study paediatricians collected data on infantile AD at repeated follow-up examinations during the first year of life. At 6.5 years, paediatricians performed skin prick tests and parents reported asthma and AD symptoms during the prior year. In addition, parents and teachers completed the Strength and Difficulties Questionnaire, which includes scales on hyperactivity/inattention, emotional problems, conduct problems, peer problems and prosocial behaviours. Results: Physician-diagnosed AD in the first year of life was not associated with increased risk for behavioural problems at 6.5 years. Emotional problems at 6.5 years were more common among children with AD symptoms (OR: 2.24, 95% CI: 1.62-3.12) and asthma symptoms (OR: 1.45; 95% CI: 1.07-1.96) during the past year at 6.5 years and ORs for children with symptoms of more severe AD and asthma were also higher. AD in the past year was also associated with probable hyperactivity/inattention disorder at 6.5 years (OR: 2.05; 95% CI: 1.09-3.84). Other subscales of the SDQ were not related to asthma or AD symptoms during the past year. Conclusions and clinical relevance: Children with AD symptoms were at higher risk for concomitant hyperactivity/inattention and emotional disorder, and children with asthma symptoms were at higher risk of having concomitant emotional problems. However, AD during infancy did not predict childhood behaviours.

KW - asthma

KW - atopic dermatitis

KW - behaviour,dermatology

KW - epidemiology

KW - paediatrics

KW - PROBIT

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M3 - Article

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SN - 0954-7894

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JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

IS - 9

ER -

Associations of atopic dermatitis and asthma with child behaviour: Results from the PROBIT cohort

Abstract

Keywords

UN SDGs

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