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Associations of smoking and alcohol consumption with healthy ageing: a systematic review and meta-analysis of longitudinal studies

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Associations of smoking and alcohol consumption with healthy ageing : a systematic review and meta-analysis of longitudinal studies. / Daskalopoulou, Christina; Stubbs, Brendon; Kralj, Carolina; Koukounari, Artemis; Prince, Martin; Prina, A Matthew.

In: BMJ open, Vol. 8, No. 4, 17.04.2018, p. e019540.

Research output: Contribution to journalArticle

Harvard

Daskalopoulou, C, Stubbs, B, Kralj, C, Koukounari, A, Prince, M & Prina, AM 2018, 'Associations of smoking and alcohol consumption with healthy ageing: a systematic review and meta-analysis of longitudinal studies', BMJ open, vol. 8, no. 4, pp. e019540. https://doi.org/10.1136/bmjopen-2017-019540

APA

Daskalopoulou, C., Stubbs, B., Kralj, C., Koukounari, A., Prince, M., & Prina, A. M. (2018). Associations of smoking and alcohol consumption with healthy ageing: a systematic review and meta-analysis of longitudinal studies. BMJ open, 8(4), e019540. https://doi.org/10.1136/bmjopen-2017-019540

Vancouver

Daskalopoulou C, Stubbs B, Kralj C, Koukounari A, Prince M, Prina AM. Associations of smoking and alcohol consumption with healthy ageing: a systematic review and meta-analysis of longitudinal studies. BMJ open. 2018 Apr 17;8(4):e019540. https://doi.org/10.1136/bmjopen-2017-019540

Author

Daskalopoulou, Christina ; Stubbs, Brendon ; Kralj, Carolina ; Koukounari, Artemis ; Prince, Martin ; Prina, A Matthew. / Associations of smoking and alcohol consumption with healthy ageing : a systematic review and meta-analysis of longitudinal studies. In: BMJ open. 2018 ; Vol. 8, No. 4. pp. e019540.

Bibtex Download

@article{6d486dfb283347b08f930d0bf0e61844,
title = "Associations of smoking and alcohol consumption with healthy ageing: a systematic review and meta-analysis of longitudinal studies",
abstract = "OBJECTIVES: The number of older people is growing across the world; however, quantitative synthesis of studies examining the impact of lifestyle factors on the ageing process is rare. We conducted a systematic review and meta-analysis of longitudinal studies to synthesise the associations of smoking and alcohol consumption with healthy ageing (HA).METHODS: Major electronic databases were searched from inception to March 2017 (prospectively registered systematic reviews registration number CRD42016038130). Studies were assessed for methodological quality. Random-effect meta-analysis was performed to calculate pooled ORs and 95% CI.RESULTS: In total, we identified 28 studies (n=184 543); 27 studies reported results on smoking, 22 on alcohol consumption. 23 studies reported a significant positive association of never or former smoking with HA and 4 non-significant. 12 studies reported a significant positive association of alcohol consumption with HA, 9 no association and 1 negative. Meta-analysis revealed increased pooled OR of HA for never smokers compared with current smokers (2.36, 95% CI 2.03 to 2.75), never smokers compared with former smokers (1.32, 95% CI 1.23 to 1.41), former or never smokers compared with current smokers (1.72, 95% CI 1.20 to 2.47), never smokers compared with past or current smokers (1.29, 95% CI 1.16 to 1.43); drinkers compared with non-drinkers (1.28, 95% CI 1.08 to 1.52), light drinkers compared with non-drinkers (1.12, 95% CI 1.03 to 1.22), moderate drinkers compared with non-drinkers (1.35, 95% CI 0.93 to 1.97) and high drinkers compared with non-drinkers (1.25, 95% CI 1.09 to 1.44). There was considerable heterogeneity in the definition and measurement of HA and alcohol consumption.CONCLUSIONS: There is consistent evidence from longitudinal studies that smoking is negatively associated with HA. The associations of alcohol consumption with HA are equivocal. Future research should focus on the implementation of a single metric of HA, on the use of consistent drinking assessment among studies and on a full-range of confounding adjustment. Our research also highlighted the limited research on ageing in low-and-middle-income countries.",
author = "Christina Daskalopoulou and Brendon Stubbs and Carolina Kralj and Artemis Koukounari and Martin Prince and Prina, {A Matthew}",
note = "{\textcopyright} Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.",
year = "2018",
month = apr,
day = "17",
doi = "10.1136/bmjopen-2017-019540",
language = "English",
volume = "8",
pages = "e019540",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Associations of smoking and alcohol consumption with healthy ageing

T2 - a systematic review and meta-analysis of longitudinal studies

AU - Daskalopoulou, Christina

AU - Stubbs, Brendon

AU - Kralj, Carolina

AU - Koukounari, Artemis

AU - Prince, Martin

AU - Prina, A Matthew

N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2018/4/17

Y1 - 2018/4/17

N2 - OBJECTIVES: The number of older people is growing across the world; however, quantitative synthesis of studies examining the impact of lifestyle factors on the ageing process is rare. We conducted a systematic review and meta-analysis of longitudinal studies to synthesise the associations of smoking and alcohol consumption with healthy ageing (HA).METHODS: Major electronic databases were searched from inception to March 2017 (prospectively registered systematic reviews registration number CRD42016038130). Studies were assessed for methodological quality. Random-effect meta-analysis was performed to calculate pooled ORs and 95% CI.RESULTS: In total, we identified 28 studies (n=184 543); 27 studies reported results on smoking, 22 on alcohol consumption. 23 studies reported a significant positive association of never or former smoking with HA and 4 non-significant. 12 studies reported a significant positive association of alcohol consumption with HA, 9 no association and 1 negative. Meta-analysis revealed increased pooled OR of HA for never smokers compared with current smokers (2.36, 95% CI 2.03 to 2.75), never smokers compared with former smokers (1.32, 95% CI 1.23 to 1.41), former or never smokers compared with current smokers (1.72, 95% CI 1.20 to 2.47), never smokers compared with past or current smokers (1.29, 95% CI 1.16 to 1.43); drinkers compared with non-drinkers (1.28, 95% CI 1.08 to 1.52), light drinkers compared with non-drinkers (1.12, 95% CI 1.03 to 1.22), moderate drinkers compared with non-drinkers (1.35, 95% CI 0.93 to 1.97) and high drinkers compared with non-drinkers (1.25, 95% CI 1.09 to 1.44). There was considerable heterogeneity in the definition and measurement of HA and alcohol consumption.CONCLUSIONS: There is consistent evidence from longitudinal studies that smoking is negatively associated with HA. The associations of alcohol consumption with HA are equivocal. Future research should focus on the implementation of a single metric of HA, on the use of consistent drinking assessment among studies and on a full-range of confounding adjustment. Our research also highlighted the limited research on ageing in low-and-middle-income countries.

AB - OBJECTIVES: The number of older people is growing across the world; however, quantitative synthesis of studies examining the impact of lifestyle factors on the ageing process is rare. We conducted a systematic review and meta-analysis of longitudinal studies to synthesise the associations of smoking and alcohol consumption with healthy ageing (HA).METHODS: Major electronic databases were searched from inception to March 2017 (prospectively registered systematic reviews registration number CRD42016038130). Studies were assessed for methodological quality. Random-effect meta-analysis was performed to calculate pooled ORs and 95% CI.RESULTS: In total, we identified 28 studies (n=184 543); 27 studies reported results on smoking, 22 on alcohol consumption. 23 studies reported a significant positive association of never or former smoking with HA and 4 non-significant. 12 studies reported a significant positive association of alcohol consumption with HA, 9 no association and 1 negative. Meta-analysis revealed increased pooled OR of HA for never smokers compared with current smokers (2.36, 95% CI 2.03 to 2.75), never smokers compared with former smokers (1.32, 95% CI 1.23 to 1.41), former or never smokers compared with current smokers (1.72, 95% CI 1.20 to 2.47), never smokers compared with past or current smokers (1.29, 95% CI 1.16 to 1.43); drinkers compared with non-drinkers (1.28, 95% CI 1.08 to 1.52), light drinkers compared with non-drinkers (1.12, 95% CI 1.03 to 1.22), moderate drinkers compared with non-drinkers (1.35, 95% CI 0.93 to 1.97) and high drinkers compared with non-drinkers (1.25, 95% CI 1.09 to 1.44). There was considerable heterogeneity in the definition and measurement of HA and alcohol consumption.CONCLUSIONS: There is consistent evidence from longitudinal studies that smoking is negatively associated with HA. The associations of alcohol consumption with HA are equivocal. Future research should focus on the implementation of a single metric of HA, on the use of consistent drinking assessment among studies and on a full-range of confounding adjustment. Our research also highlighted the limited research on ageing in low-and-middle-income countries.

U2 - 10.1136/bmjopen-2017-019540

DO - 10.1136/bmjopen-2017-019540

M3 - Article

C2 - 29666127

VL - 8

SP - e019540

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 4

ER -

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