King's College London

Research portal

Ateroesclerosis coronaria en pacientes hipertensos: el papel de la variabilidad genética del fibrinógeno

Research output: Contribution to journalArticle

Standard

Ateroesclerosis coronaria en pacientes hipertensos : el papel de la variabilidad genética del fibrinógeno. / Papageorgiou, Nikolaos; Briasoulis, Alexandros; Hatzis, Georgios; Androulakis, Emmanuel; Kozanitou, Maria; Miliou, Antigoni; Charakida, Marietta; Zacharia, Effimia; Papaioannou, Spyridon; Paroutoglou, Ioannis; Siasos, Gerasimos; Pallantza, Zoi; Tousoulis, Dimitris.

In: Revista Espanola de Cardiologia, Vol. 70, No. 1, 01.01.2017, p. 34-41.

Research output: Contribution to journalArticle

Harvard

Papageorgiou, N, Briasoulis, A, Hatzis, G, Androulakis, E, Kozanitou, M, Miliou, A, Charakida, M, Zacharia, E, Papaioannou, S, Paroutoglou, I, Siasos, G, Pallantza, Z & Tousoulis, D 2017, 'Ateroesclerosis coronaria en pacientes hipertensos: el papel de la variabilidad genética del fibrinógeno', Revista Espanola de Cardiologia, vol. 70, no. 1, pp. 34-41. https://doi.org/10.1016/j.recesp.2016.05.027

APA

Papageorgiou, N., Briasoulis, A., Hatzis, G., Androulakis, E., Kozanitou, M., Miliou, A., ... Tousoulis, D. (2017). Ateroesclerosis coronaria en pacientes hipertensos: el papel de la variabilidad genética del fibrinógeno. Revista Espanola de Cardiologia, 70(1), 34-41. https://doi.org/10.1016/j.recesp.2016.05.027

Vancouver

Papageorgiou N, Briasoulis A, Hatzis G, Androulakis E, Kozanitou M, Miliou A et al. Ateroesclerosis coronaria en pacientes hipertensos: el papel de la variabilidad genética del fibrinógeno. Revista Espanola de Cardiologia. 2017 Jan 1;70(1):34-41. https://doi.org/10.1016/j.recesp.2016.05.027

Author

Papageorgiou, Nikolaos ; Briasoulis, Alexandros ; Hatzis, Georgios ; Androulakis, Emmanuel ; Kozanitou, Maria ; Miliou, Antigoni ; Charakida, Marietta ; Zacharia, Effimia ; Papaioannou, Spyridon ; Paroutoglou, Ioannis ; Siasos, Gerasimos ; Pallantza, Zoi ; Tousoulis, Dimitris. / Ateroesclerosis coronaria en pacientes hipertensos : el papel de la variabilidad genética del fibrinógeno. In: Revista Espanola de Cardiologia. 2017 ; Vol. 70, No. 1. pp. 34-41.

Bibtex Download

@article{1fc308beb0d34940bbd4ffd828ee1eb7,
title = "Ateroesclerosis coronaria en pacientes hipertensos: el papel de la variabilidad gen{\'e}tica del fibrin{\'o}geno",
abstract = "Introduction and objectives We examined whether the rs180070 and rs2070011 polymorphisms of the fibrinogen gene could affect the risk of coronary artery disease in hypertensive patients by modifying the inflammatory process and coagulation. Methods A total of 744 participants underwent coronary angiography due to symptoms of stable angina, while hypertension was present in 332 patients. Results The presence of the A allele (rs180070) was associated with significantly high levels of fibrinogen in hypertensive patients (P =.05). On multivariate analysis, A homozygosity (rs180070) (β = 0.257 ± 18.6; P <.001), but not hypertension status (β = 0.05 ± 11.9; P =.29) was an independent predictor of fibrinogen levels. In hypertensive patients, higher fibrinogen levels > 443 mg/dL (odds ratio = 3.50; 95{\%} confidence interval, 1.14-10.90; P =.029), but not A homozygosity (odds ratio = 3.00; 95{\%} confidence interval, 0.78-11.90; P =.110) were independent predictors of the presence of coronary artery disease. Moreover, interleukin-6 levels were higher in A homozygotes for the rs180070 polymorphism compared with all other genotypes (P =.046). Indeed, this genotype was the only adjusted independent predictor of interleukin-6 levels (β = 0.151 ± 0.642; P =.032). It was also associated with higher D-dimer levels in hypertension compared with G allele carriers (P =.048). Conclusions The presence of A homozygosity (rs180070) is associated with increased levels of inflammatory mediators and a higher incidence of angiographic coronary artery disease. Importantly, fibrinogen is an independent predictor of the angiographic presence of coronary artery disease in hypertensive patients. Full English text available from: www.revespcardiol.org/en",
keywords = "Coronary artery disease, Fibrinogen, Hypertension, Polymorphisms",
author = "Nikolaos Papageorgiou and Alexandros Briasoulis and Georgios Hatzis and Emmanuel Androulakis and Maria Kozanitou and Antigoni Miliou and Marietta Charakida and Effimia Zacharia and Spyridon Papaioannou and Ioannis Paroutoglou and Gerasimos Siasos and Zoi Pallantza and Dimitris Tousoulis",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.recesp.2016.05.027",
language = "Spanish",
volume = "70",
pages = "34--41",
journal = "Revista Espanola de Cardiologia",
issn = "0300-8932",
publisher = "Ediciones Doyma, S.L.",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Ateroesclerosis coronaria en pacientes hipertensos

T2 - el papel de la variabilidad genética del fibrinógeno

AU - Papageorgiou, Nikolaos

AU - Briasoulis, Alexandros

AU - Hatzis, Georgios

AU - Androulakis, Emmanuel

AU - Kozanitou, Maria

AU - Miliou, Antigoni

AU - Charakida, Marietta

AU - Zacharia, Effimia

AU - Papaioannou, Spyridon

AU - Paroutoglou, Ioannis

AU - Siasos, Gerasimos

AU - Pallantza, Zoi

AU - Tousoulis, Dimitris

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Introduction and objectives We examined whether the rs180070 and rs2070011 polymorphisms of the fibrinogen gene could affect the risk of coronary artery disease in hypertensive patients by modifying the inflammatory process and coagulation. Methods A total of 744 participants underwent coronary angiography due to symptoms of stable angina, while hypertension was present in 332 patients. Results The presence of the A allele (rs180070) was associated with significantly high levels of fibrinogen in hypertensive patients (P =.05). On multivariate analysis, A homozygosity (rs180070) (β = 0.257 ± 18.6; P <.001), but not hypertension status (β = 0.05 ± 11.9; P =.29) was an independent predictor of fibrinogen levels. In hypertensive patients, higher fibrinogen levels > 443 mg/dL (odds ratio = 3.50; 95% confidence interval, 1.14-10.90; P =.029), but not A homozygosity (odds ratio = 3.00; 95% confidence interval, 0.78-11.90; P =.110) were independent predictors of the presence of coronary artery disease. Moreover, interleukin-6 levels were higher in A homozygotes for the rs180070 polymorphism compared with all other genotypes (P =.046). Indeed, this genotype was the only adjusted independent predictor of interleukin-6 levels (β = 0.151 ± 0.642; P =.032). It was also associated with higher D-dimer levels in hypertension compared with G allele carriers (P =.048). Conclusions The presence of A homozygosity (rs180070) is associated with increased levels of inflammatory mediators and a higher incidence of angiographic coronary artery disease. Importantly, fibrinogen is an independent predictor of the angiographic presence of coronary artery disease in hypertensive patients. Full English text available from: www.revespcardiol.org/en

AB - Introduction and objectives We examined whether the rs180070 and rs2070011 polymorphisms of the fibrinogen gene could affect the risk of coronary artery disease in hypertensive patients by modifying the inflammatory process and coagulation. Methods A total of 744 participants underwent coronary angiography due to symptoms of stable angina, while hypertension was present in 332 patients. Results The presence of the A allele (rs180070) was associated with significantly high levels of fibrinogen in hypertensive patients (P =.05). On multivariate analysis, A homozygosity (rs180070) (β = 0.257 ± 18.6; P <.001), but not hypertension status (β = 0.05 ± 11.9; P =.29) was an independent predictor of fibrinogen levels. In hypertensive patients, higher fibrinogen levels > 443 mg/dL (odds ratio = 3.50; 95% confidence interval, 1.14-10.90; P =.029), but not A homozygosity (odds ratio = 3.00; 95% confidence interval, 0.78-11.90; P =.110) were independent predictors of the presence of coronary artery disease. Moreover, interleukin-6 levels were higher in A homozygotes for the rs180070 polymorphism compared with all other genotypes (P =.046). Indeed, this genotype was the only adjusted independent predictor of interleukin-6 levels (β = 0.151 ± 0.642; P =.032). It was also associated with higher D-dimer levels in hypertension compared with G allele carriers (P =.048). Conclusions The presence of A homozygosity (rs180070) is associated with increased levels of inflammatory mediators and a higher incidence of angiographic coronary artery disease. Importantly, fibrinogen is an independent predictor of the angiographic presence of coronary artery disease in hypertensive patients. Full English text available from: www.revespcardiol.org/en

KW - Coronary artery disease

KW - Fibrinogen

KW - Hypertension

KW - Polymorphisms

UR - http://www.scopus.com/inward/record.url?scp=84996564388&partnerID=8YFLogxK

U2 - 10.1016/j.recesp.2016.05.027

DO - 10.1016/j.recesp.2016.05.027

M3 - Article

C2 - 27553289

AN - SCOPUS:84996564388

VL - 70

SP - 34

EP - 41

JO - Revista Espanola de Cardiologia

JF - Revista Espanola de Cardiologia

SN - 0300-8932

IS - 1

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454