Atherosclerosis-Multiple Pathways to Lesional Macrophages

TY - JOUR

T1 - Atherosclerosis-Multiple Pathways to Lesional Macrophages

AU - Schulz, Christian

AU - Massberg, Steffen

PY - 2014/6/4

Y1 - 2014/6/4

N2 - Atherosclerosis is a chronic inflammatory disease that manifests in multiple vascular beds and frequently culminates in ischemic events, including myocardial infarction. Blood monocytes that are recruited to the inflamed vascular wall develop into inflammatory macrophages and foam cells, which contribute to pathogenesis at many stages of this disease and, therefore, represent a target for therapeutic interventions. Recently, alternate sources of macrophages have been identified. Here, we discuss the origin and molecular regulation of macrophages and highlight recent conceptual changes that may shape the development of effective treatments.

AB - Atherosclerosis is a chronic inflammatory disease that manifests in multiple vascular beds and frequently culminates in ischemic events, including myocardial infarction. Blood monocytes that are recruited to the inflamed vascular wall develop into inflammatory macrophages and foam cells, which contribute to pathogenesis at many stages of this disease and, therefore, represent a target for therapeutic interventions. Recently, alternate sources of macrophages have been identified. Here, we discuss the origin and molecular regulation of macrophages and highlight recent conceptual changes that may shape the development of effective treatments.

KW - HEMATOPOIETIC PROGENITOR CELLS

KW - TISSUE-RESIDENT MACROPHAGES

KW - APOLIPOPROTEIN-E

KW - MYELOID CELLS

KW - MONOCYTES

KW - INFLAMMATION

KW - MICE

KW - RECRUITMENT

KW - ADVENTITIA

KW - MECHANISMS

U2 - 10.1126/scitranslmed.3008922

DO - 10.1126/scitranslmed.3008922

M3 - Article

SN - 1946-6234

VL - 6

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 239

M1 - 239ps2

ER -