ATP-responsive Mn(ii)-based T1 contrast agent for MRI

Sellamuthu Anbu; Lawerence Kenning; Graeme J. Stasiuk

doi:10.1039/d3cc03430e

ATP-responsive Mn(ii)-based T₁ contrast agent for MRI

Sellamuthu Anbu^*, Lawerence Kenning, Graeme J. Stasiuk^*

^*Corresponding author for this work

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

Abstract

A novel diacetylpyridylcarbohydrazide-DAPyCOHz-based manganese(ii) chelate with dipicolylamine/zinc(ii) (DPA/Zn²⁺) arms (MnLDPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T₁ contrast applications. Compound 2 shows enhanced relaxivity (r₁ = 11.52 mM⁻¹ s⁻¹) upon selective ATP binding over other phosphates.

Original language	English
Pages (from-to)	13623-13626
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	91
DOIs	https://doi.org/10.1039/d3cc03430e
Publication status	Published - 19 Sept 2023

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abstract = "A novel diacetylpyridylcarbohydrazide-DAPyCOHz-based manganese(ii) chelate with dipicolylamine/zinc(ii) (DPA/Zn2+) arms (MnLDPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T1 contrast applications. Compound 2 shows enhanced relaxivity (r1 = 11.52 mM−1 s−1) upon selective ATP binding over other phosphates.",

author = "Sellamuthu Anbu and Lawerence Kenning and Stasiuk, {Graeme J.}",

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AU - Anbu, Sellamuthu

AU - Kenning, Lawerence

AU - Stasiuk, Graeme J.

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AB - A novel diacetylpyridylcarbohydrazide-DAPyCOHz-based manganese(ii) chelate with dipicolylamine/zinc(ii) (DPA/Zn2+) arms (MnLDPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T1 contrast applications. Compound 2 shows enhanced relaxivity (r1 = 11.52 mM−1 s−1) upon selective ATP binding over other phosphates.

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ATP-responsive Mn(ii)-based T₁ contrast agent for MRI

Abstract

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