TY - CHAP
T1 - Atrial Fibrillation Mechanisms
T2 - 9th Latin American Congress on Biomedical Engineering, CLAIB 2022 and 28th Brazilian Congress on Biomedical Engineering, CBEB 2022
AU - Antunes, M. E.T.
AU - Campos, F. O.
AU - Sandoval, I.
AU - Siles, J. G.
AU - Uzelac, I.
AU - Salinet, J.
N1 - Publisher Copyright:
© 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2023
Y1 - 2023
N2 - Atrial Fibrillation (AF) is the most common cardiac arrhythmia worldwide; it is complex and can be multifactorial, and the underlying mechanisms are not yet completely understood, limiting treatment and reducing patients’ quality of life. Computational modelling has been shown to play an important role at improving current knowledge of AF. This study aims to simulate a normal heart condition as a planar wavefront propagation, and the three main AF mechanisms: ectopic foci, rotors and multiple and continuous intra-atrial reentries. This can be done through the OpenCARP platform, using its python framework called carputils, and applying Courtemanche’s human atrial action potential model. Action potential duration, local activation time and conduction velocity are estimated and compared, alongside the simulation images themselves. In summary, the mechanisms believed to underlie AF were reproduced here using 2D in-silico simulations performed in a standard computer. Action potential and cell-to-cell propagation variables had their roles identified in the mechanisms triggering and maintaining.
AB - Atrial Fibrillation (AF) is the most common cardiac arrhythmia worldwide; it is complex and can be multifactorial, and the underlying mechanisms are not yet completely understood, limiting treatment and reducing patients’ quality of life. Computational modelling has been shown to play an important role at improving current knowledge of AF. This study aims to simulate a normal heart condition as a planar wavefront propagation, and the three main AF mechanisms: ectopic foci, rotors and multiple and continuous intra-atrial reentries. This can be done through the OpenCARP platform, using its python framework called carputils, and applying Courtemanche’s human atrial action potential model. Action potential duration, local activation time and conduction velocity are estimated and compared, alongside the simulation images themselves. In summary, the mechanisms believed to underlie AF were reproduced here using 2D in-silico simulations performed in a standard computer. Action potential and cell-to-cell propagation variables had their roles identified in the mechanisms triggering and maintaining.
KW - Atrial fibrillation
KW - Computational modelling
KW - Mechanisms
UR - http://www.scopus.com/inward/record.url?scp=85180636432&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-49401-7_14
DO - 10.1007/978-3-031-49401-7_14
M3 - Conference paper
AN - SCOPUS:85180636432
SN - 9783031494000
T3 - IFMBE Proceedings
SP - 139
EP - 146
BT - 9th Latin American Congress on Biomedical Engineering and 28th Brazilian Congress on Biomedical Engineering - Proceedings of CLAIB and CBEB 2022—Volume 1
A2 - Marques, Jefferson Luiz Brum
A2 - Rodrigues, Cesar Ramos
A2 - Suzuki, Daniela Ota Hisayasu
A2 - García Ojeda, Renato
A2 - Marino Neto, José
PB - Springer Science and Business Media Deutschland GmbH
Y2 - 24 October 2022 through 28 October 2022
ER -