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Atrio-ventricular deformation and heart failure in Ebstein's Anomaly — A cardiovascular magnetic resonance study

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Atrio-ventricular deformation and heart failure in Ebstein's Anomaly — A cardiovascular magnetic resonance study. / Steinmetz, Michael; Broder, Marike; Hösch, Olga; Lamata, Pablo; Kutty, Shelby; Kowallick, Johannes T.; Staab, Wieland; Ritter, Christian Oliver; Hasenfuß, Gerd; Paul, Thomas; Lotz, Joachim; Schuster, Andreas.

In: International Journal of Cardiology, 03.02.2018.

Research output: Contribution to journalArticle

Harvard

Steinmetz, M, Broder, M, Hösch, O, Lamata, P, Kutty, S, Kowallick, JT, Staab, W, Ritter, CO, Hasenfuß, G, Paul, T, Lotz, J & Schuster, A 2018, 'Atrio-ventricular deformation and heart failure in Ebstein's Anomaly — A cardiovascular magnetic resonance study' International Journal of Cardiology. DOI: 10.1016/j.ijcard.2017.11.097

APA

Steinmetz, M., Broder, M., Hösch, O., Lamata, P., Kutty, S., Kowallick, J. T., ... Schuster, A. (2018). Atrio-ventricular deformation and heart failure in Ebstein's Anomaly — A cardiovascular magnetic resonance study. International Journal of Cardiology. DOI: 10.1016/j.ijcard.2017.11.097

Vancouver

Steinmetz M, Broder M, Hösch O, Lamata P, Kutty S, Kowallick JT et al. Atrio-ventricular deformation and heart failure in Ebstein's Anomaly — A cardiovascular magnetic resonance study. International Journal of Cardiology. 2018 Feb 3. Available from, DOI: 10.1016/j.ijcard.2017.11.097

Author

Steinmetz, Michael ; Broder, Marike ; Hösch, Olga ; Lamata, Pablo ; Kutty, Shelby ; Kowallick, Johannes T. ; Staab, Wieland ; Ritter, Christian Oliver ; Hasenfuß, Gerd ; Paul, Thomas ; Lotz, Joachim ; Schuster, Andreas. / Atrio-ventricular deformation and heart failure in Ebstein's Anomaly — A cardiovascular magnetic resonance study. In: International Journal of Cardiology. 2018

Bibtex Download

@article{2ebe07fa8f504382aa3563854f034859,
title = "Atrio-ventricular deformation and heart failure in Ebstein\{textquoteleft}s Anomaly — A cardiovascular magnetic resonance study",
abstract = "Purpose We aimed to quantify atrial and ventricular myocardial deformation in Ebstein\{textquoteleft}s Anomaly (EA) in a case-control study with cardiovascular magnetic resonance (CMR) feature tracking and to correlate changes in cardiac performance with the severity of disease and clinical heart failure parameters. Materials and methods Atrial and ventricular deformation was measured using CMR feature tracking in 30 EA and 20 healthy control subjects. Atrial performance was characterized using longitudinal strain and strain rate parameters for reservoir function, conduit function and booster pump function. Ventricular performance was characterized using RV and LV global longitudinal strain (εl) and LV circumferential and radial strain (εc and εr). Volumetric measurements for the ventricles including the Total Right/Left-Volume-Index (R/L-Volume-Index) and heart failure markers (BNP, NYHA class) were also quantified. Results EA patients showed significantly impaired right atrial performance, which correlated with heart failure markers (NYHA, BNP, R/L-Volume-Index). LA function in EA patients was also impaired with atrial contractile function correlating with NYHA class. EA patients exhibited impaired RV myocardial deformation, also with a significant correlation with heart failure markers. Conclusion CMR feature tracking can be used to quantify ventricular and atrial function in a complex cardiac malformation such as EA. EA is characterized by impaired quantitative right heart atrio-ventricular deformation, which is associated with heart failure severity. While LV function remains preserved, there is also significant impairment of LA function. These quantitative performance parameters may represent early markers of cardiac deterioration of potential value in the clinical management of EA.",
keywords = "Ebstein\{textquoteleft}s Anomaly, CMR, Feature tracking, Strain, R/L-Volume-Index, Heart failure",
author = "Michael Steinmetz and Marike Broder and Olga H\{"o}sch and Pablo Lamata and Shelby Kutty and Kowallick, {Johannes T.} and Wieland Staab and Ritter, {Christian Oliver} and Gerd Hasenfu\{ss} and Thomas Paul and Joachim Lotz and Andreas Schuster",
year = "2018",
month = "2",
day = "3",
doi = "10.1016/j.ijcard.2017.11.097",
language = "English",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Atrio-ventricular deformation and heart failure in Ebstein's Anomaly — A cardiovascular magnetic resonance study

AU - Steinmetz,Michael

AU - Broder,Marike

AU - Hösch,Olga

AU - Lamata,Pablo

AU - Kutty,Shelby

AU - Kowallick,Johannes T.

AU - Staab,Wieland

AU - Ritter,Christian Oliver

AU - Hasenfuß,Gerd

AU - Paul,Thomas

AU - Lotz,Joachim

AU - Schuster,Andreas

PY - 2018/2/3

Y1 - 2018/2/3

N2 - Purpose We aimed to quantify atrial and ventricular myocardial deformation in Ebstein's Anomaly (EA) in a case-control study with cardiovascular magnetic resonance (CMR) feature tracking and to correlate changes in cardiac performance with the severity of disease and clinical heart failure parameters. Materials and methods Atrial and ventricular deformation was measured using CMR feature tracking in 30 EA and 20 healthy control subjects. Atrial performance was characterized using longitudinal strain and strain rate parameters for reservoir function, conduit function and booster pump function. Ventricular performance was characterized using RV and LV global longitudinal strain (εl) and LV circumferential and radial strain (εc and εr). Volumetric measurements for the ventricles including the Total Right/Left-Volume-Index (R/L-Volume-Index) and heart failure markers (BNP, NYHA class) were also quantified. Results EA patients showed significantly impaired right atrial performance, which correlated with heart failure markers (NYHA, BNP, R/L-Volume-Index). LA function in EA patients was also impaired with atrial contractile function correlating with NYHA class. EA patients exhibited impaired RV myocardial deformation, also with a significant correlation with heart failure markers. Conclusion CMR feature tracking can be used to quantify ventricular and atrial function in a complex cardiac malformation such as EA. EA is characterized by impaired quantitative right heart atrio-ventricular deformation, which is associated with heart failure severity. While LV function remains preserved, there is also significant impairment of LA function. These quantitative performance parameters may represent early markers of cardiac deterioration of potential value in the clinical management of EA.

AB - Purpose We aimed to quantify atrial and ventricular myocardial deformation in Ebstein's Anomaly (EA) in a case-control study with cardiovascular magnetic resonance (CMR) feature tracking and to correlate changes in cardiac performance with the severity of disease and clinical heart failure parameters. Materials and methods Atrial and ventricular deformation was measured using CMR feature tracking in 30 EA and 20 healthy control subjects. Atrial performance was characterized using longitudinal strain and strain rate parameters for reservoir function, conduit function and booster pump function. Ventricular performance was characterized using RV and LV global longitudinal strain (εl) and LV circumferential and radial strain (εc and εr). Volumetric measurements for the ventricles including the Total Right/Left-Volume-Index (R/L-Volume-Index) and heart failure markers (BNP, NYHA class) were also quantified. Results EA patients showed significantly impaired right atrial performance, which correlated with heart failure markers (NYHA, BNP, R/L-Volume-Index). LA function in EA patients was also impaired with atrial contractile function correlating with NYHA class. EA patients exhibited impaired RV myocardial deformation, also with a significant correlation with heart failure markers. Conclusion CMR feature tracking can be used to quantify ventricular and atrial function in a complex cardiac malformation such as EA. EA is characterized by impaired quantitative right heart atrio-ventricular deformation, which is associated with heart failure severity. While LV function remains preserved, there is also significant impairment of LA function. These quantitative performance parameters may represent early markers of cardiac deterioration of potential value in the clinical management of EA.

KW - Ebstein's Anomaly

KW - CMR

KW - Feature tracking

KW - Strain

KW - R/L-Volume-Index

KW - Heart failure

U2 - 10.1016/j.ijcard.2017.11.097

DO - 10.1016/j.ijcard.2017.11.097

M3 - Article

JO - International Journal of Cardiology

T2 - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -

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