Attention regulation in women with ADHD and women with bipolar disorder: an ex-Gaussian approach

Isabella Vainieri; Nicoletta Adamo; Giorgia Michelini; Viryanaga Kitsune; Philip John Elliot Asherson; Jonna Pauliina Kuntsi

doi:https://doi.org/10.1016/j.psychres.2019.112729

Attention regulation in women with ADHD and women with bipolar disorder: an ex-Gaussian approach

Isabella Vainieri, Nicoletta Adamo, Giorgia Michelini, Viryanaga Kitsune, Philip John Elliot Asherson, Jonna Pauliina Kuntsi

Stony Brook University

Research output: Contribution to journal › Article › peer-review

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Abstract

Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) show certain overlapping features, such as increased reaction time variability. Here, we tested whether more detailed ex-Gaussian reaction time distribution measures identify shared or disorder-specific impairments in ADHD and BD. The total assessed sample consisted of 60 women (20 each in ADHD, BD and control groups). We compared the groups on ex-Gaussian measures of mu, sigma, and tau from a flanker task (congruent and incongruent conditions), an oddball task, and a four-choice reaction time task (baseline and fast-incentive conditions of the `fast task'). The ex-Gaussian measures mu and sigma reflect the speed and variability of typical responses, while tau captures variability in infrequent slow responses. Compared to controls, both ADHD and BD groups showed significantly increased tau in the fast task baseline condition. Participants with BD further showed a significantly increased sigma compared to ADHD and control groups in the flanker task incongruent condition. Our findings indicate that the ex-Gaussian approach is informative in detecting shared and disorder-specific cognitive impairments in ADHD and BD that may represent objective markers of these two disorders.

Original language	English
Article number	112729
Journal	Psychiatry Research
Volume	285
DOIs	https://doi.org/10.1016/j.psychres.2019.112729
Publication status	Published - 27 Mar 2020

Keywords

Attention
Attention-deficit/hyperactivity disorder (ADHD)
Bipolar disorder (BD)
Reaction time (RT)
Reaction time variability (RTV)
ex-Gaussian decomposition

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Attention regulation in women_VAINIERIA_Accepted3December2019_GOLD AAMAccepted author manuscript, 79.7 KB

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abstract = "Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) show certain overlapping features, such as increased reaction time variability. Here, we tested whether more detailed ex-Gaussian reaction time distribution measures identify shared or disorder-specific impairments in ADHD and BD. The total assessed sample consisted of 60 women (20 each in ADHD, BD and control groups). We compared the groups on ex-Gaussian measures of mu, sigma, and tau from a flanker task (congruent and incongruent conditions), an oddball task, and a four-choice reaction time task (baseline and fast-incentive conditions of the `fast task'). The ex-Gaussian measures mu and sigma reflect the speed and variability of typical responses, while tau captures variability in infrequent slow responses. Compared to controls, both ADHD and BD groups showed significantly increased tau in the fast task baseline condition. Participants with BD further showed a significantly increased sigma compared to ADHD and control groups in the flanker task incongruent condition. Our findings indicate that the ex-Gaussian approach is informative in detecting shared and disorder-specific cognitive impairments in ADHD and BD that may represent objective markers of these two disorders.",

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Attention regulation in women with ADHD and women with bipolar disorder: an ex-Gaussian approach

Abstract

Keywords

UN SDGs

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