Atypical antipsychotic drugs and tardive dyskinesia: relevance of D-2 receptor affinity

TY - JOUR

T1 - Atypical antipsychotic drugs and tardive dyskinesia: relevance of D-2 receptor affinity

AU - Bressan, R A

AU - Jones, H M

AU - Pilowsky, L S

PY - 2004/3

Y1 - 2004/3

N2 - Evidence suggests atypical antipsychotic treatment is associated with a Lower incidence of tardive dyskinesia (TD) than typical antipsychotic drugs, and is a potential antidyskinetic treatment. We present the case of a middle-aged woman never previously exposed to antipsychotic treatment who developed TD after 6 months of olanzapine monotherapy. Substitution of quetiapine for otanzapine alleviated her TD symptoms. The case demonstrates that atypical antipsychotic drugs have different effects in relation to TD. Potential psychopharmacological mechanisms explaining these differences are discussed, highlighting the importance of D-2 receptor occupancy by atypical antipsychotic drugs for TD.

AB - Evidence suggests atypical antipsychotic treatment is associated with a Lower incidence of tardive dyskinesia (TD) than typical antipsychotic drugs, and is a potential antidyskinetic treatment. We present the case of a middle-aged woman never previously exposed to antipsychotic treatment who developed TD after 6 months of olanzapine monotherapy. Substitution of quetiapine for otanzapine alleviated her TD symptoms. The case demonstrates that atypical antipsychotic drugs have different effects in relation to TD. Potential psychopharmacological mechanisms explaining these differences are discussed, highlighting the importance of D-2 receptor occupancy by atypical antipsychotic drugs for TD.

UR - http://www.scopus.com/inward/record.url?scp=2442498598&partnerID=8YFLogxK

U2 - 10.1177/0269881104040251

DO - 10.1177/0269881104040251

M3 - Article

SN - 1461-7285

VL - 18

SP - 124

EP - 127

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

IS - 1

ER -