Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis

Julio Vaquerizo-Serrano, Gonzalo Salazar de Pablo, Jatinder Singh, Paramala Santosh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Psychotic experiences can occur in autism spectrum disorders (ASD). Some of the ASD individuals with these experiences may fulfil Clinical High-Risk for Psychosis (CHR-P) criteria. A systematic literature search was performed to review the information on ASD and CHR-P. A meta-analysis of the proportion of CHR-P in ASD was conducted. The systematic review included 13 studies. The mean age of ASD individuals across the included studies was 11.09 years. The Attenuated Psychosis Syndrome subgroup was the most frequently reported. Four studies were meta-analysed, showing that 11.6% of CHR-P individuals have an ASD diagnosis. Symptoms of prodromal psychosis may be present in individuals with ASD. The transition from CHR-P to psychosis is not affected by ASD.

Original languageEnglish
JournalJournal of Autism and Developmental Disorders
Volume52
Issue number4
Early online date15 May 2021
DOIs
Publication statusE-pub ahead of print - 15 May 2021

Keywords

  • Autism spectrum disorders
  • Clinical high-risk for psychosis
  • Meta-analysis
  • Prodromal psychosis
  • Psychosis
  • Systematic review

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