Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis

Julio Vaquerizo-Serrano; Gonzalo Salazar de Pablo; Jatinder Singh; Paramala Santosh

doi:10.1007/s10803-021-05046-0

Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis

Julio Vaquerizo-Serrano, Gonzalo Salazar de Pablo, Jatinder Singh, Paramala Santosh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Psychotic experiences can occur in autism spectrum disorders (ASD). Some of the ASD individuals with these experiences may fulfil Clinical High-Risk for Psychosis (CHR-P) criteria. A systematic literature search was performed to review the information on ASD and CHR-P. A meta-analysis of the proportion of CHR-P in ASD was conducted. The systematic review included 13 studies. The mean age of ASD individuals across the included studies was 11.09 years. The Attenuated Psychosis Syndrome subgroup was the most frequently reported. Four studies were meta-analysed, showing that 11.6% of CHR-P individuals have an ASD diagnosis. Symptoms of prodromal psychosis may be present in individuals with ASD. The transition from CHR-P to psychosis is not affected by ASD.

Original language	English
Journal	Journal of Autism and Developmental Disorders
Volume	52
Issue number	4
Early online date	15 May 2021
DOIs	https://doi.org/10.1007/s10803-021-05046-0
Publication status	E-pub ahead of print - 15 May 2021

Keywords

Autism spectrum disorders
Clinical high-risk for psychosis
Meta-analysis
Prodromal psychosis
Psychosis
Systematic review

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10.1007/s10803-021-05046-0

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title = "Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis",

abstract = "Psychotic experiences can occur in autism spectrum disorders (ASD). Some of the ASD individuals with these experiences may fulfil Clinical High-Risk for Psychosis (CHR-P) criteria. A systematic literature search was performed to review the information on ASD and CHR-P. A meta-analysis of the proportion of CHR-P in ASD was conducted. The systematic review included 13 studies. The mean age of ASD individuals across the included studies was 11.09 years. The Attenuated Psychosis Syndrome subgroup was the most frequently reported. Four studies were meta-analysed, showing that 11.6% of CHR-P individuals have an ASD diagnosis. Symptoms of prodromal psychosis may be present in individuals with ASD. The transition from CHR-P to psychosis is not affected by ASD.",

keywords = "Autism spectrum disorders, Clinical high-risk for psychosis, Meta-analysis, Prodromal psychosis, Psychosis, Systematic review",

author = "Julio Vaquerizo-Serrano and {Salazar de Pablo}, Gonzalo and Jatinder Singh and Paramala Santosh",

note = "Funding Information: Dr Julio Vaquerizo-Serrano and Gonzalo Salazar de Pablo are supported by the Alicia Koplowitz Foundation. Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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AU - Salazar de Pablo, Gonzalo

AU - Singh, Jatinder

AU - Santosh, Paramala

N1 - Funding Information: Dr Julio Vaquerizo-Serrano and Gonzalo Salazar de Pablo are supported by the Alicia Koplowitz Foundation. Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/5/15

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N2 - Psychotic experiences can occur in autism spectrum disorders (ASD). Some of the ASD individuals with these experiences may fulfil Clinical High-Risk for Psychosis (CHR-P) criteria. A systematic literature search was performed to review the information on ASD and CHR-P. A meta-analysis of the proportion of CHR-P in ASD was conducted. The systematic review included 13 studies. The mean age of ASD individuals across the included studies was 11.09 years. The Attenuated Psychosis Syndrome subgroup was the most frequently reported. Four studies were meta-analysed, showing that 11.6% of CHR-P individuals have an ASD diagnosis. Symptoms of prodromal psychosis may be present in individuals with ASD. The transition from CHR-P to psychosis is not affected by ASD.

AB - Psychotic experiences can occur in autism spectrum disorders (ASD). Some of the ASD individuals with these experiences may fulfil Clinical High-Risk for Psychosis (CHR-P) criteria. A systematic literature search was performed to review the information on ASD and CHR-P. A meta-analysis of the proportion of CHR-P in ASD was conducted. The systematic review included 13 studies. The mean age of ASD individuals across the included studies was 11.09 years. The Attenuated Psychosis Syndrome subgroup was the most frequently reported. Four studies were meta-analysed, showing that 11.6% of CHR-P individuals have an ASD diagnosis. Symptoms of prodromal psychosis may be present in individuals with ASD. The transition from CHR-P to psychosis is not affected by ASD.

KW - Autism spectrum disorders

KW - Clinical high-risk for psychosis

KW - Meta-analysis

KW - Prodromal psychosis

KW - Psychosis

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ER -

Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis

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Keywords

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