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Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition

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Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition. / Sugranyes, Gisela; Kyriakopoulos, Marinos; Corrigall, Richard; Taylor, Eric; Frangou, Sophia.

In: PL o S One , Vol. 6, No. 10, 25322, 05.10.2011.

Research output: Contribution to journalArticle

Harvard

Sugranyes, G, Kyriakopoulos, M, Corrigall, R, Taylor, E & Frangou, S 2011, 'Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition', PL o S One , vol. 6, no. 10, 25322. https://doi.org/10.1371/journal.pone.0025322

APA

Sugranyes, G., Kyriakopoulos, M., Corrigall, R., Taylor, E., & Frangou, S. (2011). Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition. PL o S One , 6(10), [25322]. https://doi.org/10.1371/journal.pone.0025322

Vancouver

Sugranyes G, Kyriakopoulos M, Corrigall R, Taylor E, Frangou S. Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition. PL o S One . 2011 Oct 5;6(10). 25322. https://doi.org/10.1371/journal.pone.0025322

Author

Sugranyes, Gisela ; Kyriakopoulos, Marinos ; Corrigall, Richard ; Taylor, Eric ; Frangou, Sophia. / Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition. In: PL o S One . 2011 ; Vol. 6, No. 10.

Bibtex Download

@article{de7d653e961f4d73bfcbd70b004d5617,
title = "Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition",
abstract = "Context: Impaired social cognition is a cardinal feature of Autism Spectrum Disorders (ASD) and Schizophrenia (SZ). However, the functional neuroanatomy of social cognition in either disorder remains unclear due to variability in primary literature. Additionally, it is not known whether deficits in ASD and SZ arise from similar or disease-specific disruption of the social cognition network.Objective: To identify regions most robustly implicated in social cognition processing in SZ and ASD.Data Sources: Systematic review of English language articles using MEDLINE (1995-2010) and reference lists.Study Selection: Studies were required to use fMRI to compare ASD or SZ subjects to a matched healthy control group, provide coordinates in standard stereotactic space, and employ standardized facial emotion recognition (FER) or theory of mind (TOM) paradigms.Data Extraction: Activation foci from studies meeting inclusion criteria (n = 33) were subjected to a quantitative voxel-based meta-analysis using activation likelihood estimation, and encompassed 146 subjects with ASD, 336 SZ patients and 492 healthy controls.Results: Both SZ and ASD showed medial prefrontal hypoactivation, which was more pronounced in ASD, while ventrolateral prefrontal dysfunction was associated mostly with SZ. Amygdala hypoactivation was observed in SZ patients during FER and in ASD during more complex ToM tasks. Both disorders were associated with hypoactivation within the Superior Temporal Sulcus (STS) during ToM tasks, but activation in these regions was increased in ASD during affect processing. Disease-specific differences were noted in somatosensory engagement, which was increased in SZ and decreased in ASD. Reduced thalamic activation was uniquely seen in SZ.Conclusions: Reduced frontolimbic and STS engagement emerged as a shared feature of social cognition deficits in SZ and ASD. However, there were disease-and stimulus-specific differences. These findings may aid future studies on SZ and ASD and facilitate the formulation of new hypotheses regarding their pathophysiology.",
keywords = "FACIAL EMOTION DISCRIMINATION, VOXEL-BASED METAANALYSIS, ONSET SCHIZOPHRENIA, FUNCTIONING AUTISM, ASPERGER-SYNDROME, FRONTAL-CORTEX, FEARFUL FACES, BRAIN, MIND, AMYGDALA",
author = "Gisela Sugranyes and Marinos Kyriakopoulos and Richard Corrigall and Eric Taylor and Sophia Frangou",
year = "2011",
month = "10",
day = "5",
doi = "10.1371/journal.pone.0025322",
language = "English",
volume = "6",
journal = "PL o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition

AU - Sugranyes, Gisela

AU - Kyriakopoulos, Marinos

AU - Corrigall, Richard

AU - Taylor, Eric

AU - Frangou, Sophia

PY - 2011/10/5

Y1 - 2011/10/5

N2 - Context: Impaired social cognition is a cardinal feature of Autism Spectrum Disorders (ASD) and Schizophrenia (SZ). However, the functional neuroanatomy of social cognition in either disorder remains unclear due to variability in primary literature. Additionally, it is not known whether deficits in ASD and SZ arise from similar or disease-specific disruption of the social cognition network.Objective: To identify regions most robustly implicated in social cognition processing in SZ and ASD.Data Sources: Systematic review of English language articles using MEDLINE (1995-2010) and reference lists.Study Selection: Studies were required to use fMRI to compare ASD or SZ subjects to a matched healthy control group, provide coordinates in standard stereotactic space, and employ standardized facial emotion recognition (FER) or theory of mind (TOM) paradigms.Data Extraction: Activation foci from studies meeting inclusion criteria (n = 33) were subjected to a quantitative voxel-based meta-analysis using activation likelihood estimation, and encompassed 146 subjects with ASD, 336 SZ patients and 492 healthy controls.Results: Both SZ and ASD showed medial prefrontal hypoactivation, which was more pronounced in ASD, while ventrolateral prefrontal dysfunction was associated mostly with SZ. Amygdala hypoactivation was observed in SZ patients during FER and in ASD during more complex ToM tasks. Both disorders were associated with hypoactivation within the Superior Temporal Sulcus (STS) during ToM tasks, but activation in these regions was increased in ASD during affect processing. Disease-specific differences were noted in somatosensory engagement, which was increased in SZ and decreased in ASD. Reduced thalamic activation was uniquely seen in SZ.Conclusions: Reduced frontolimbic and STS engagement emerged as a shared feature of social cognition deficits in SZ and ASD. However, there were disease-and stimulus-specific differences. These findings may aid future studies on SZ and ASD and facilitate the formulation of new hypotheses regarding their pathophysiology.

AB - Context: Impaired social cognition is a cardinal feature of Autism Spectrum Disorders (ASD) and Schizophrenia (SZ). However, the functional neuroanatomy of social cognition in either disorder remains unclear due to variability in primary literature. Additionally, it is not known whether deficits in ASD and SZ arise from similar or disease-specific disruption of the social cognition network.Objective: To identify regions most robustly implicated in social cognition processing in SZ and ASD.Data Sources: Systematic review of English language articles using MEDLINE (1995-2010) and reference lists.Study Selection: Studies were required to use fMRI to compare ASD or SZ subjects to a matched healthy control group, provide coordinates in standard stereotactic space, and employ standardized facial emotion recognition (FER) or theory of mind (TOM) paradigms.Data Extraction: Activation foci from studies meeting inclusion criteria (n = 33) were subjected to a quantitative voxel-based meta-analysis using activation likelihood estimation, and encompassed 146 subjects with ASD, 336 SZ patients and 492 healthy controls.Results: Both SZ and ASD showed medial prefrontal hypoactivation, which was more pronounced in ASD, while ventrolateral prefrontal dysfunction was associated mostly with SZ. Amygdala hypoactivation was observed in SZ patients during FER and in ASD during more complex ToM tasks. Both disorders were associated with hypoactivation within the Superior Temporal Sulcus (STS) during ToM tasks, but activation in these regions was increased in ASD during affect processing. Disease-specific differences were noted in somatosensory engagement, which was increased in SZ and decreased in ASD. Reduced thalamic activation was uniquely seen in SZ.Conclusions: Reduced frontolimbic and STS engagement emerged as a shared feature of social cognition deficits in SZ and ASD. However, there were disease-and stimulus-specific differences. These findings may aid future studies on SZ and ASD and facilitate the formulation of new hypotheses regarding their pathophysiology.

KW - FACIAL EMOTION DISCRIMINATION

KW - VOXEL-BASED METAANALYSIS

KW - ONSET SCHIZOPHRENIA

KW - FUNCTIONING AUTISM

KW - ASPERGER-SYNDROME

KW - FRONTAL-CORTEX

KW - FEARFUL FACES

KW - BRAIN

KW - MIND

KW - AMYGDALA

U2 - 10.1371/journal.pone.0025322

DO - 10.1371/journal.pone.0025322

M3 - Article

VL - 6

JO - PL o S One

JF - PL o S One

SN - 1932-6203

IS - 10

M1 - 25322

ER -

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