TY - JOUR
T1 - Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project
AU - Bastiani, Matteo
AU - Andersson, Jesper
AU - Cordero-Grande, Lucilio
AU - Murgasova, Maria
AU - Hutter, Jana
AU - Price, Anthony N
AU - Makropoulos, Antonios
AU - Fitzgibbon, Sean P
AU - Hughes, Emer
AU - Rueckert, Daniel
AU - Victor, Suresh
AU - Rutherford, Mary
AU - Edwards, A David
AU - Smith, Steve
AU - Tournier, Jacques-Donald
AU - Hajnal, Joseph V
AU - Jbabdi, Saad
AU - Sotiropoulos, Stamatios N
N1 - Copyright © 2018. Published by Elsevier Inc.
PY - 2018/5/28
Y1 - 2018/5/28
N2 - The developing Human Connectome Project is set to create and make available to the scientific community a 4-dimensional map of functional and structural cerebral connectivity from 20 to 44 weeks post-menstrual age, to allow exploration of the genetic and environmental influences on brain development, and the relation between connectivity and neurocognitive function. A large set of multi-modal MRI data from fetuses and newborn infants is currently being acquired, along with genetic, clinical and developmental information. In this overview, we describe the neonatal diffusion MRI (dMRI) image processing pipeline and the structural connectivity aspect of the project. Neonatal dMRI data poses specific challenges, and standard analysis techniques used for adult data are not directly applicable. We have developed a processing pipeline that deals directly with neonatal-specific issues, such as severe motion and motion-related artefacts, small brain sizes, high brain water content and reduced anisotropy. This pipeline allows automated analysis of in-vivo dMRI data, probes tissue microstructure, reconstructs a number of major white matter tracts, and includes an automated quality control framework that identifies processing issues or inconsistencies. We here describe the pipeline and present an exemplar analysis of data from 140 infants imaged at 38-44 weeks post-menstrual age.
AB - The developing Human Connectome Project is set to create and make available to the scientific community a 4-dimensional map of functional and structural cerebral connectivity from 20 to 44 weeks post-menstrual age, to allow exploration of the genetic and environmental influences on brain development, and the relation between connectivity and neurocognitive function. A large set of multi-modal MRI data from fetuses and newborn infants is currently being acquired, along with genetic, clinical and developmental information. In this overview, we describe the neonatal diffusion MRI (dMRI) image processing pipeline and the structural connectivity aspect of the project. Neonatal dMRI data poses specific challenges, and standard analysis techniques used for adult data are not directly applicable. We have developed a processing pipeline that deals directly with neonatal-specific issues, such as severe motion and motion-related artefacts, small brain sizes, high brain water content and reduced anisotropy. This pipeline allows automated analysis of in-vivo dMRI data, probes tissue microstructure, reconstructs a number of major white matter tracts, and includes an automated quality control framework that identifies processing issues or inconsistencies. We here describe the pipeline and present an exemplar analysis of data from 140 infants imaged at 38-44 weeks post-menstrual age.
KW - Diffusion MRI
KW - Tractography
KW - Quality control
KW - Brain
KW - Connectome
KW - Newborn
UR - http://www.scopus.com/inward/record.url?scp=85048783963&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2018.05.064
DO - 10.1016/j.neuroimage.2018.05.064
M3 - Review article
C2 - 29852283
SN - 1053-8119
JO - NeuroImage
JF - NeuroImage
ER -