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Automated quantitative stress perfusion cardiac magnetic resonance in pediatric patients

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number699497
JournalFrontiers in Pediatrics
Volume9
DOIs
Accepted/In press5 Aug 2021
Published3 Sep 2021

Bibliographical note

Funding Information: Funding. This work was supported by the King's College London & Imperial College London EPSRC Centre for Doctoral Training in Medical Imaging [EP/L015226/1]; Philips Healthcare; The Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust; The NIHR Cardiovascular MedTech Co-operative; The British Heart Foundation [TG/18/2/33768]; and The Centre of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC [WT 203148/Z/16/Z]. Funding Information: This work was supported by the King’s College London & Imperial College London EPSRC Centre for Doctoral Training in Medical Imaging [EP/L015226/1]; Philips Healthcare; The Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust; The NIHR Cardiovascular MedTech Co-operative; The British Heart Foundation [TG/18/2/33768]; and The Centre of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC [WT 203148/Z/16/Z]. Publisher Copyright: © Copyright © 2021 Scannell, Hasaneen, Greil, Hussain, Razavi, Lee, Pushparajah, Duong and Chiribiri. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

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  • fped-09-699497

    fped_09_699497.pdf, 903 KB, application/pdf

    Uploaded date:08 Sep 2021

    Version:Final published version

    Licence:CC BY

King's Authors

Abstract

Background: Myocardial ischemia occurs in pediatrics, as a result of both congenital and acquired heart diseases, and can lead to further adverse cardiac events if untreated. The aim of this work is to assess the feasibility of fully automated, high resolution, quantitative stress myocardial perfusion cardiac magnetic resonance (CMR) in a cohort of pediatric patients and to evaluate its agreement with the coronary anatomical status of the patients. Methods: Fourteen pediatric patients, with 16 scans, who underwent dual-bolus stress perfusion CMR were retrospectively analyzed. All patients also had anatomical coronary assessment with either CMR, CT, or X-ray angiography. The perfusion CMR images were automatically processed and quantified using an analysis pipeline previously developed in adults. Results: Automated perfusion quantification was successful in 15/16 cases. The coronary perfusion territories supplied by vessels affected by a medium/large aneurysm or stenosis (according to the AHA guidelines), induced by Kawasaki disease, an anomalous origin, or interarterial course had significantly reduced myocardial blood flow (MBF) (median (interquartile range), 1.26 (1.05, 1.67) ml/min/g) as compared to territories supplied by unaffected coronaries [2.57 (2.02, 2.69) ml/min/g, p < 0.001] and territories supplied by vessels with a small aneurysm [2.52 (2.45, 2.83) ml/min/g, p = 0.002]. Conclusion: Automatic CMR-derived MBF quantification is feasible in pediatric patients, and the technology could be potentially used for objective non-invasive assessment of ischemia in children with congenital and acquired heart diseases.

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