Automated Structure Solution With autoSHARP

C. Vonrhein, E. Blanc, P. Roversi, G. Bricogne

Research output: Chapter in Book/Report/Conference proceedingChapter


We present here the automated structure solution pipeline “autoSHARP.” It is built around the heavy-atom refinement and phasing program SHARP, the density modification program SOLOMON, and the ARP/wARP package for automated model building and refinement (using REFMAC). It allows fully automated structure solution, from merged reflection data to an initial model, without any user intervention. We describe and discuss the preparation of the user input, the data flow through the pipeline, and the various results obtained throughout the procedure.
Original languageEnglish
Title of host publicationMacromolecular Crystallography Protocols, Volume 2: Structure determination Methods in Molecular Biology 364
EditorsS. Doublie
Place of PublicationTotowa (NJ)
PublisherHumana Press
Pages215 - 230
Number of pages16
Publication statusPublished - 2006

Publication series

NameMethods in Molecular Biology


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