Abstract
Sulfur-[18F]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We report a fully automated radiolabelling procedure for the synthesis of a [18F]SO3F-bearing prostate specific membrane antigen (PSMA) targeted ligand ([18F]5) using the GE FASTLab™ cassette-based platform in a 25.0 ± 2.6% radiochemical yield (decay corrected). Uptake in vitro and in vivo correlated with PSMA expression, and the radioligand exhibited favourable biodistribution and pharmacokinetic profiles.
Original language | English |
---|---|
Pages (from-to) | 2403-2407 |
Number of pages | 5 |
Journal | Reaction Chemistry and Engineering |
Volume | 8 |
Issue number | 10 |
DOIs | |
Publication status | Published - 21 Aug 2023 |