Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform

Zixuan Yang, Chris Barnes, Juozas Domarkas, Joanna Koch-Paszkowski, John Wright, Ala Amgheib, Isaline Renard, Ruisi Fu, Stephen Archibald, Eric O. Aboagye*, Louis Allott*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Sulfur-[18F]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We report a fully automated radiolabelling procedure for the synthesis of a [18F]SO3F-bearing prostate specific membrane antigen (PSMA) targeted ligand ([18F]5) using the GE FASTLab™ cassette-based platform in a 25.0 ± 2.6% radiochemical yield (decay corrected). Uptake in vitro and in vivo correlated with PSMA expression, and the radioligand exhibited favourable biodistribution and pharmacokinetic profiles.

Original languageEnglish
Pages (from-to)2403-2407
Number of pages5
JournalReaction Chemistry and Engineering
Volume8
Issue number10
DOIs
Publication statusPublished - 21 Aug 2023

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