Image registration driven by similarity measures that are simple functions of voxel intensities is now widely used in medical applications. Validation of registration in general remains an unsolved problem; measurement of registration error usually requires manual intervention. This paper presents a general framework for automatically estimating the scale of spatial registration error. The error is estimated from a statistical analysis of the scale-space of a residual image constructed with the same assumptions used to choose the image similarity measure. The analysis identifies the most significant scale of voxel clusters in the residual image for a coarse estimate of error. A partial volume correction is then applied to estimate finer and sub-voxel displacements. We describe the algorithm and present the results of an evaluation on rigid-body registrations where the ground-truth error is known. Automated measures may ultimately provide a useful estimate of the scale of registration error.
|LECTURE NOTES IN COMPUTER SCIENCE
|7th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2004)
|1/01/2004 → …