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Automatic T2* determination for quantification of iron load in heart and liver: A comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods

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Automatic T2* determination for quantification of iron load in heart and liver : A comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods. / Hedström, Erik; Voigt, Tobias; Greil, Gerald; Schaeffter, Tobias; Nagel, Eike.

In: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, Vol. 37, No. 3, 05.2017, p. 299-304.

Research output: Contribution to journalArticle

Harvard

Hedström, E, Voigt, T, Greil, G, Schaeffter, T & Nagel, E 2017, 'Automatic T2* determination for quantification of iron load in heart and liver: A comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods', CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, vol. 37, no. 3, pp. 299-304. https://doi.org/10.1111/cpf.12303

APA

Hedström, E., Voigt, T., Greil, G., Schaeffter, T., & Nagel, E. (2017). Automatic T2* determination for quantification of iron load in heart and liver: A comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, 37(3), 299-304. https://doi.org/10.1111/cpf.12303

Vancouver

Hedström E, Voigt T, Greil G, Schaeffter T, Nagel E. Automatic T2* determination for quantification of iron load in heart and liver: A comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2017 May;37(3):299-304. https://doi.org/10.1111/cpf.12303

Author

Hedström, Erik ; Voigt, Tobias ; Greil, Gerald ; Schaeffter, Tobias ; Nagel, Eike. / Automatic T2* determination for quantification of iron load in heart and liver : A comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods. In: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2017 ; Vol. 37, No. 3. pp. 299-304.

Bibtex Download

@article{dbdb65f7f7584fd3b3aa751b2cee3597,
title = "Automatic T2* determination for quantification of iron load in heart and liver: A comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods",
abstract = "Purpose: To validate ironload T2* by automatic inline Maximum Likelihood Estimate (MLE) with k-space Rician noise correction, against the manual and automated truncation, as well as offset methods, in phantoms and in heart and liver in patients. Methods: Twenty-five patients and an iron-oxide phantom were scanned at 1.5T using 2 multi-echo gradient-echo sequences. All parameters were identical (voxel 2-3 × 2-3 × 10 mm3, 10 echoes, TR = 26 ms, FA = 20°, BW = 833 Hz, SENSE = 2) except for TE (cardiac: TE1 = 2·5 ms, ΔTE = 2·5 ms; liver: TE1 = 1·2 ms, ΔTE = 1·5 ms). Phantoms were scanned at 1 and 32 signal averages (NSA), with NSA32 representing low-noise reference. Results: Phantoms: MLE showed low variability between NSA1 and NSA32 (0·02 ± 0·29 ms, CI ±0·21 ms). Between methods, no difference was shown (MLE versus all: <0·31 ms, CI < ±0·35 ms). Patients: No differences were found between methods in heart (MLE versus all: <-0·22 ms, CI < ±0·75 ms) or liver (MLE versus all: <0·12 ms, CI < ±0·26 ms). Conclusions: The automatic inline MLE method is comparable to the general reference standards for determining cardiac and liver T2* for ironload in man. An automatic inline method may simplify ironload assessment, particularly in centres seeing fewer cases.",
keywords = "Algorithm, Automated, Heart, Ironload, Liver, Validation",
author = "Erik Hedstr{\"o}m and Tobias Voigt and Gerald Greil and Tobias Schaeffter and Eike Nagel",
year = "2017",
month = "5",
doi = "10.1111/cpf.12303",
language = "English",
volume = "37",
pages = "299--304",
journal = "CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING",
issn = "1475-0961",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Automatic T2* determination for quantification of iron load in heart and liver

T2 - A comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods

AU - Hedström, Erik

AU - Voigt, Tobias

AU - Greil, Gerald

AU - Schaeffter, Tobias

AU - Nagel, Eike

PY - 2017/5

Y1 - 2017/5

N2 - Purpose: To validate ironload T2* by automatic inline Maximum Likelihood Estimate (MLE) with k-space Rician noise correction, against the manual and automated truncation, as well as offset methods, in phantoms and in heart and liver in patients. Methods: Twenty-five patients and an iron-oxide phantom were scanned at 1.5T using 2 multi-echo gradient-echo sequences. All parameters were identical (voxel 2-3 × 2-3 × 10 mm3, 10 echoes, TR = 26 ms, FA = 20°, BW = 833 Hz, SENSE = 2) except for TE (cardiac: TE1 = 2·5 ms, ΔTE = 2·5 ms; liver: TE1 = 1·2 ms, ΔTE = 1·5 ms). Phantoms were scanned at 1 and 32 signal averages (NSA), with NSA32 representing low-noise reference. Results: Phantoms: MLE showed low variability between NSA1 and NSA32 (0·02 ± 0·29 ms, CI ±0·21 ms). Between methods, no difference was shown (MLE versus all: <0·31 ms, CI < ±0·35 ms). Patients: No differences were found between methods in heart (MLE versus all: <-0·22 ms, CI < ±0·75 ms) or liver (MLE versus all: <0·12 ms, CI < ±0·26 ms). Conclusions: The automatic inline MLE method is comparable to the general reference standards for determining cardiac and liver T2* for ironload in man. An automatic inline method may simplify ironload assessment, particularly in centres seeing fewer cases.

AB - Purpose: To validate ironload T2* by automatic inline Maximum Likelihood Estimate (MLE) with k-space Rician noise correction, against the manual and automated truncation, as well as offset methods, in phantoms and in heart and liver in patients. Methods: Twenty-five patients and an iron-oxide phantom were scanned at 1.5T using 2 multi-echo gradient-echo sequences. All parameters were identical (voxel 2-3 × 2-3 × 10 mm3, 10 echoes, TR = 26 ms, FA = 20°, BW = 833 Hz, SENSE = 2) except for TE (cardiac: TE1 = 2·5 ms, ΔTE = 2·5 ms; liver: TE1 = 1·2 ms, ΔTE = 1·5 ms). Phantoms were scanned at 1 and 32 signal averages (NSA), with NSA32 representing low-noise reference. Results: Phantoms: MLE showed low variability between NSA1 and NSA32 (0·02 ± 0·29 ms, CI ±0·21 ms). Between methods, no difference was shown (MLE versus all: <0·31 ms, CI < ±0·35 ms). Patients: No differences were found between methods in heart (MLE versus all: <-0·22 ms, CI < ±0·75 ms) or liver (MLE versus all: <0·12 ms, CI < ±0·26 ms). Conclusions: The automatic inline MLE method is comparable to the general reference standards for determining cardiac and liver T2* for ironload in man. An automatic inline method may simplify ironload assessment, particularly in centres seeing fewer cases.

KW - Algorithm

KW - Automated

KW - Heart

KW - Ironload

KW - Liver

KW - Validation

UR - http://www.scopus.com/inward/record.url?scp=84952802352&partnerID=8YFLogxK

U2 - 10.1111/cpf.12303

DO - 10.1111/cpf.12303

M3 - Article

VL - 37

SP - 299

EP - 304

JO - CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

JF - CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

SN - 1475-0961

IS - 3

ER -

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