Autophagic receptors Nbr1 and p62 coregulate skeletal remodeling

Sarah Waters, Katie Marchbank, Ellen Solomon, Caroline A. Whitehouse

Research output: Contribution to journalEditorialpeer-review

17 Citations (Scopus)


Skeletal remodeling is an ongoing process requiring the coordinated action of different cell types to maintain homeostatic control of bone synthesis and degradation. Mutations in p62/SQSTM1 are associated with sporadic and 5q35-linked Paget Disease of Bone (PDB), characterized by focal increased bone turnover. These mutations cluster in the ubiquitin associated (UBA) domain and are thought to lead to enhancement of NF kappa B pathway activation involved in osteoclastogenesis and hyper-responsiveness to receptor activator of nuclear factor kappa B ligand (RANKL). The structurally similar selective autophagic receptor, Nbr1, binds to LC3 and p62 and is sequestered into autophagosomes, whereas it accumulates in autophagic-deficient tissues. We have shown that truncation of Nbr1 in a murine model, where it can still interact with p62 but not LC3, leads to increased osteoblast differentiation and activity in vivo. This results in an age-dependent increase in bone mass and bone mineral density. This is a molecular consequence of loss of autophagy receptor function via deletion of its C-terminal UBA domain, and/or modulation of the p38 MAPK cellular signaling pathway.
Original languageEnglish
Pages (from-to)981 - 983
Number of pages3
Issue number7
Publication statusPublished - 1 Oct 2010


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