Avaliação do funcionamento do eixo HPA em deprimidos por meio de medidas basais: Revisão sistemática da literatura e análise das metodologias utilizadas

Lúcia Helena Moraes Vilela; Mario Francisco Juruena

doi:10.1590/0047-2085000000031

Avaliação do funcionamento do eixo HPA em deprimidos por meio de medidas basais: Revisão sistemática da literatura e análise das metodologias utilizadas

Translated title of the contribution: Assessment of HPA axis functioning in patients with depression through baseline measures: A systematic literature review and analysis of the used methodologies

Lúcia Helena Moraes Vilela, Mario Francisco Juruena^*

^*Corresponding author for this work

Centre for Affective Disorders

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Objective: We performed a systematic literature review in order to assess the hypothalamic-pituitary-adrenal (HPA) axis activity in depressed considering the baseline measurements of the hormones of this axis and perform a critical analysis of the methodologies used. Methods: We performed search for articles in the databases PubMed and SciELO. In the first database, was introduced the keywords: “depressive disorder”, “HPA axis” and in the second used the terms “depression” or “depressão” and “HPA” or “HPA axis”. We limit to research in adult humans, in English and Portuguese, from the year 2000 until 2011. Results: Of the 27 selected articles, obtained HPA axis hyperactivity, unregulated activity, hypoactivity or remains unchanged. These results depend on the variables and hormones studied, collected fluid: plasma, urine, saliva, cerebrospinal fluid; the time of collection, the number of collections, the subtype of the depressive disease, among others. Conclusion: The results do not have consensus on HPA activity. Considering the variables studied, the HPA axis, in most cases, it appears dysfunctional in the presence of depression.

Translated title of the contribution	Assessment of HPA axis functioning in patients with depression through baseline measures: A systematic literature review and analysis of the used methodologies
Original language	Portuguese
Pages (from-to)	232-241
Number of pages	10
Journal	Jornal Brasileiro de Psiquiatria
Volume	63
Issue number	3
DOIs	https://doi.org/10.1590/0047-2085000000031
Publication status	Published - 1 Jul 2014

Keywords

Baseline measurement
Cortisol
Critical analisys
Depression
HPA axis
Systematic review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1590/0047-2085000000031

Cite this

@article{580f5ce54ea444f68a71c20b3686af45,

title = "Avalia{\c c}{\~a}o do funcionamento do eixo HPA em deprimidos por meio de medidas basais: Revis{\~a}o sistem{\'a}tica da literatura e an{\'a}lise das metodologias utilizadas",

abstract = "Objective: We performed a systematic literature review in order to assess the hypothalamic-pituitary-adrenal (HPA) axis activity in depressed considering the baseline measurements of the hormones of this axis and perform a critical analysis of the methodologies used. Methods: We performed search for articles in the databases PubMed and SciELO. In the first database, was introduced the keywords: “depressive disorder”, “HPA axis” and in the second used the terms “depression” or “depress{\~a}o” and “HPA” or “HPA axis”. We limit to research in adult humans, in English and Portuguese, from the year 2000 until 2011. Results: Of the 27 selected articles, obtained HPA axis hyperactivity, unregulated activity, hypoactivity or remains unchanged. These results depend on the variables and hormones studied, collected fluid: plasma, urine, saliva, cerebrospinal fluid; the time of collection, the number of collections, the subtype of the depressive disease, among others. Conclusion: The results do not have consensus on HPA activity. Considering the variables studied, the HPA axis, in most cases, it appears dysfunctional in the presence of depression.",

keywords = "Baseline measurement, Cortisol, Critical analisys, Depression, HPA axis, Systematic review",

author = "Vilela, {L{\'u}cia Helena Moraes} and Juruena, {Mario Francisco}",

year = "2014",

month = jul,

day = "1",

doi = "10.1590/0047-2085000000031",

language = "Portuguese",

volume = "63",

pages = "232--241",

journal = "Jornal Brasileiro de Psiquiatria",

issn = "0047-2085",

publisher = "Editora Cientifica Nacional Ltda",

number = "3",

}

Avaliação do funcionamento do eixo HPA em deprimidos por meio de medidas basais : Revisão sistemática da literatura e análise das metodologias utilizadas. / Vilela, Lúcia Helena Moraes; Juruena, Mario Francisco.

In: Jornal Brasileiro de Psiquiatria, Vol. 63, No. 3, 01.07.2014, p. 232-241.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Avaliação do funcionamento do eixo HPA em deprimidos por meio de medidas basais

T2 - Revisão sistemática da literatura e análise das metodologias utilizadas

AU - Vilela, Lúcia Helena Moraes

AU - Juruena, Mario Francisco

PY - 2014/7/1

Y1 - 2014/7/1

N2 - Objective: We performed a systematic literature review in order to assess the hypothalamic-pituitary-adrenal (HPA) axis activity in depressed considering the baseline measurements of the hormones of this axis and perform a critical analysis of the methodologies used. Methods: We performed search for articles in the databases PubMed and SciELO. In the first database, was introduced the keywords: “depressive disorder”, “HPA axis” and in the second used the terms “depression” or “depressão” and “HPA” or “HPA axis”. We limit to research in adult humans, in English and Portuguese, from the year 2000 until 2011. Results: Of the 27 selected articles, obtained HPA axis hyperactivity, unregulated activity, hypoactivity or remains unchanged. These results depend on the variables and hormones studied, collected fluid: plasma, urine, saliva, cerebrospinal fluid; the time of collection, the number of collections, the subtype of the depressive disease, among others. Conclusion: The results do not have consensus on HPA activity. Considering the variables studied, the HPA axis, in most cases, it appears dysfunctional in the presence of depression.

AB - Objective: We performed a systematic literature review in order to assess the hypothalamic-pituitary-adrenal (HPA) axis activity in depressed considering the baseline measurements of the hormones of this axis and perform a critical analysis of the methodologies used. Methods: We performed search for articles in the databases PubMed and SciELO. In the first database, was introduced the keywords: “depressive disorder”, “HPA axis” and in the second used the terms “depression” or “depressão” and “HPA” or “HPA axis”. We limit to research in adult humans, in English and Portuguese, from the year 2000 until 2011. Results: Of the 27 selected articles, obtained HPA axis hyperactivity, unregulated activity, hypoactivity or remains unchanged. These results depend on the variables and hormones studied, collected fluid: plasma, urine, saliva, cerebrospinal fluid; the time of collection, the number of collections, the subtype of the depressive disease, among others. Conclusion: The results do not have consensus on HPA activity. Considering the variables studied, the HPA axis, in most cases, it appears dysfunctional in the presence of depression.

KW - Baseline measurement

KW - Cortisol

KW - Critical analisys

KW - Depression

KW - HPA axis

KW - Systematic review

UR - http://www.scopus.com/inward/record.url?scp=84911448952&partnerID=8YFLogxK

U2 - 10.1590/0047-2085000000031

DO - 10.1590/0047-2085000000031

M3 - Review article

AN - SCOPUS:84911448952

SN - 0047-2085

VL - 63

SP - 232

EP - 241

JO - Jornal Brasileiro de Psiquiatria

JF - Jornal Brasileiro de Psiquiatria

IS - 3

ER -

Avaliação do funcionamento do eixo HPA em deprimidos por meio de medidas basais: Revisão sistemática da literatura e análise das metodologias utilizadas

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this