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Basal ganglia volume and shape in anorexia nervosa

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Basal ganglia volume and shape in anorexia nervosa. / Leppanen, Jenni; Cardi, Valentina; Sedgewick, Felicity; Treasure, Janet; Tchanturia, Kate.

In: Appetite, Vol. 144, 104480, 02.10.2019.

Research output: Contribution to journalArticle

Harvard

Leppanen, J, Cardi, V, Sedgewick, F, Treasure, J & Tchanturia, K 2019, 'Basal ganglia volume and shape in anorexia nervosa', Appetite, vol. 144, 104480. https://doi.org/10.1016/j.appet.2019.104480

APA

Leppanen, J., Cardi, V., Sedgewick, F., Treasure, J., & Tchanturia, K. (2019). Basal ganglia volume and shape in anorexia nervosa. Appetite, 144, [104480]. https://doi.org/10.1016/j.appet.2019.104480

Vancouver

Leppanen J, Cardi V, Sedgewick F, Treasure J, Tchanturia K. Basal ganglia volume and shape in anorexia nervosa. Appetite. 2019 Oct 2;144. 104480. https://doi.org/10.1016/j.appet.2019.104480

Author

Leppanen, Jenni ; Cardi, Valentina ; Sedgewick, Felicity ; Treasure, Janet ; Tchanturia, Kate. / Basal ganglia volume and shape in anorexia nervosa. In: Appetite. 2019 ; Vol. 144.

Bibtex Download

@article{2153f9e2121847e7b2dea7c9158db0c5,
title = "Basal ganglia volume and shape in anorexia nervosa",
abstract = "BACKGROUND: Reward-centred models have proposed that anomalies in the basal ganglia circuitry that underlies reward learning and habit formation perpetuate anorexia nervosa (AN). The present study aimed to investigate the volume and shape of key basal ganglia regions, including the bilateral caudate, putamen, nucleus accumbens (NAcc), and globus pallidus in AN.METHODS: The present study combined data from two existing studies resulting in a sample size of 46 women with AN and 56 age-matched healthy comparison (HC) women. Group differences in volume and shape of the regions of interest were examined. Within the AN group, the impact of eating disorder characteristics on volume and shape of the basal ganglia regions were also explored.RESULTS: The shape analyses revealed inward deformations in the left caudate, right NAcc, and bilateral ventral and internus globus pallidus, and outward deformations in the right middle and posterior globus pallidus in the AN group.CONCLUSIONS: The present findings appear to fit with the theoretical models suggesting that there are alterations in the basal ganglia regions associated with habit formation and reward processing in AN. Further investigation of structural and functional connectivity of these regions in AN as well as their role in recovery would be of interest.",
keywords = "Basal ganglia, Caudate, Nucleus accumbens, Pallidum, Reward",
author = "Jenni Leppanen and Valentina Cardi and Felicity Sedgewick and Janet Treasure and Kate Tchanturia",
year = "2019",
month = "10",
day = "2",
doi = "10.1016/j.appet.2019.104480",
language = "English",
volume = "144",
journal = "Appetite",
issn = "0195-6663",
publisher = "ACADEMIC PRESS INC",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Basal ganglia volume and shape in anorexia nervosa

AU - Leppanen, Jenni

AU - Cardi, Valentina

AU - Sedgewick, Felicity

AU - Treasure, Janet

AU - Tchanturia, Kate

PY - 2019/10/2

Y1 - 2019/10/2

N2 - BACKGROUND: Reward-centred models have proposed that anomalies in the basal ganglia circuitry that underlies reward learning and habit formation perpetuate anorexia nervosa (AN). The present study aimed to investigate the volume and shape of key basal ganglia regions, including the bilateral caudate, putamen, nucleus accumbens (NAcc), and globus pallidus in AN.METHODS: The present study combined data from two existing studies resulting in a sample size of 46 women with AN and 56 age-matched healthy comparison (HC) women. Group differences in volume and shape of the regions of interest were examined. Within the AN group, the impact of eating disorder characteristics on volume and shape of the basal ganglia regions were also explored.RESULTS: The shape analyses revealed inward deformations in the left caudate, right NAcc, and bilateral ventral and internus globus pallidus, and outward deformations in the right middle and posterior globus pallidus in the AN group.CONCLUSIONS: The present findings appear to fit with the theoretical models suggesting that there are alterations in the basal ganglia regions associated with habit formation and reward processing in AN. Further investigation of structural and functional connectivity of these regions in AN as well as their role in recovery would be of interest.

AB - BACKGROUND: Reward-centred models have proposed that anomalies in the basal ganglia circuitry that underlies reward learning and habit formation perpetuate anorexia nervosa (AN). The present study aimed to investigate the volume and shape of key basal ganglia regions, including the bilateral caudate, putamen, nucleus accumbens (NAcc), and globus pallidus in AN.METHODS: The present study combined data from two existing studies resulting in a sample size of 46 women with AN and 56 age-matched healthy comparison (HC) women. Group differences in volume and shape of the regions of interest were examined. Within the AN group, the impact of eating disorder characteristics on volume and shape of the basal ganglia regions were also explored.RESULTS: The shape analyses revealed inward deformations in the left caudate, right NAcc, and bilateral ventral and internus globus pallidus, and outward deformations in the right middle and posterior globus pallidus in the AN group.CONCLUSIONS: The present findings appear to fit with the theoretical models suggesting that there are alterations in the basal ganglia regions associated with habit formation and reward processing in AN. Further investigation of structural and functional connectivity of these regions in AN as well as their role in recovery would be of interest.

KW - Basal ganglia

KW - Caudate

KW - Nucleus accumbens

KW - Pallidum

KW - Reward

UR - http://www.scopus.com/inward/record.url?scp=85072896239&partnerID=8YFLogxK

U2 - 10.1016/j.appet.2019.104480

DO - 10.1016/j.appet.2019.104480

M3 - Article

C2 - 31586464

VL - 144

JO - Appetite

JF - Appetite

SN - 0195-6663

M1 - 104480

ER -

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