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Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults

Research output: Contribution to journalArticle

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Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults. / King, Bradley R.; Rumpf, Jost Julian; Verbaanderd, Elvire; Heise, Kirstin F.; Dolfen, Nina; Sunaert, Stefan; Doyon, Julien; Classen, Joseph; Mantini, Dante; Puts, Nicolaas A.J.; Edden, Richard A.E.; Albouy, Geneviève; Swinnen, Stephan P.

In: Human Brain Mapping, Vol. 41, No. 13, 01.09.2020, p. 3680-3695.

Research output: Contribution to journalArticle

Harvard

King, BR, Rumpf, JJ, Verbaanderd, E, Heise, KF, Dolfen, N, Sunaert, S, Doyon, J, Classen, J, Mantini, D, Puts, NAJ, Edden, RAE, Albouy, G & Swinnen, SP 2020, 'Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults', Human Brain Mapping, vol. 41, no. 13, pp. 3680-3695. https://doi.org/10.1002/hbm.25041

APA

King, B. R., Rumpf, J. J., Verbaanderd, E., Heise, K. F., Dolfen, N., Sunaert, S., Doyon, J., Classen, J., Mantini, D., Puts, N. A. J., Edden, R. A. E., Albouy, G., & Swinnen, S. P. (2020). Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults. Human Brain Mapping, 41(13), 3680-3695. https://doi.org/10.1002/hbm.25041

Vancouver

King BR, Rumpf JJ, Verbaanderd E, Heise KF, Dolfen N, Sunaert S et al. Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults. Human Brain Mapping. 2020 Sep 1;41(13):3680-3695. https://doi.org/10.1002/hbm.25041

Author

King, Bradley R. ; Rumpf, Jost Julian ; Verbaanderd, Elvire ; Heise, Kirstin F. ; Dolfen, Nina ; Sunaert, Stefan ; Doyon, Julien ; Classen, Joseph ; Mantini, Dante ; Puts, Nicolaas A.J. ; Edden, Richard A.E. ; Albouy, Geneviève ; Swinnen, Stephan P. / Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults. In: Human Brain Mapping. 2020 ; Vol. 41, No. 13. pp. 3680-3695.

Bibtex Download

@article{e139546bde234860a0e873b8c29e60a1,
title = "Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults",
abstract = "Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma-aminobutyric acid (GABA) in the sensorimotor cortex, and these decreases are linked to greater learning. Less is known about the role of GABA in motor learning in healthy older adults, a knowledge gap that is surprising given the established aging-related reductions in sensorimotor GABA. Here, we examined the effects of motor learning and subsequent tDCS on sensorimotor GABA levels and resting-state functional connectivity in the brains of healthy older participants. Thirty-six older men and women completed a motor sequence learning task before receiving anodal or sham tDCS to the sensorimotor cortex. GABA-edited magnetic resonance spectroscopy of the sensorimotor cortex and resting-state (RS) functional magnetic resonance imaging data were acquired before and after learning/stimulation. At the group level, neither learning nor anodal tDCS significantly modulated GABA levels or RS connectivity among task-relevant regions. However, changes in GABA levels from the baseline to post-learning session were significantly related to motor learning magnitude, age, and baseline GABA. Moreover, the change in functional connectivity between task-relevant regions, including bilateral motor cortices, was correlated with baseline GABA levels. These data collectively indicate that motor learning-related decreases in sensorimotor GABA levels and increases in functional connectivity are limited to those older adults with higher baseline GABA levels and who learn the most. Post-learning tDCS exerted no influence on GABA levels, functional connectivity or the relationships among these variables in older adults.",
keywords = "aging, functional connectivity, functional neuroimaging, gamma-aminobutyric acid, motor learning",
author = "King, {Bradley R.} and Rumpf, {Jost Julian} and Elvire Verbaanderd and Heise, {Kirstin F.} and Nina Dolfen and Stefan Sunaert and Julien Doyon and Joseph Classen and Dante Mantini and Puts, {Nicolaas A.J.} and Edden, {Richard A.E.} and Genevi{\`e}ve Albouy and Swinnen, {Stephan P.}",
year = "2020",
month = sep,
day = "1",
doi = "10.1002/hbm.25041",
language = "English",
volume = "41",
pages = "3680--3695",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "13",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults

AU - King, Bradley R.

AU - Rumpf, Jost Julian

AU - Verbaanderd, Elvire

AU - Heise, Kirstin F.

AU - Dolfen, Nina

AU - Sunaert, Stefan

AU - Doyon, Julien

AU - Classen, Joseph

AU - Mantini, Dante

AU - Puts, Nicolaas A.J.

AU - Edden, Richard A.E.

AU - Albouy, Geneviève

AU - Swinnen, Stephan P.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma-aminobutyric acid (GABA) in the sensorimotor cortex, and these decreases are linked to greater learning. Less is known about the role of GABA in motor learning in healthy older adults, a knowledge gap that is surprising given the established aging-related reductions in sensorimotor GABA. Here, we examined the effects of motor learning and subsequent tDCS on sensorimotor GABA levels and resting-state functional connectivity in the brains of healthy older participants. Thirty-six older men and women completed a motor sequence learning task before receiving anodal or sham tDCS to the sensorimotor cortex. GABA-edited magnetic resonance spectroscopy of the sensorimotor cortex and resting-state (RS) functional magnetic resonance imaging data were acquired before and after learning/stimulation. At the group level, neither learning nor anodal tDCS significantly modulated GABA levels or RS connectivity among task-relevant regions. However, changes in GABA levels from the baseline to post-learning session were significantly related to motor learning magnitude, age, and baseline GABA. Moreover, the change in functional connectivity between task-relevant regions, including bilateral motor cortices, was correlated with baseline GABA levels. These data collectively indicate that motor learning-related decreases in sensorimotor GABA levels and increases in functional connectivity are limited to those older adults with higher baseline GABA levels and who learn the most. Post-learning tDCS exerted no influence on GABA levels, functional connectivity or the relationships among these variables in older adults.

AB - Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma-aminobutyric acid (GABA) in the sensorimotor cortex, and these decreases are linked to greater learning. Less is known about the role of GABA in motor learning in healthy older adults, a knowledge gap that is surprising given the established aging-related reductions in sensorimotor GABA. Here, we examined the effects of motor learning and subsequent tDCS on sensorimotor GABA levels and resting-state functional connectivity in the brains of healthy older participants. Thirty-six older men and women completed a motor sequence learning task before receiving anodal or sham tDCS to the sensorimotor cortex. GABA-edited magnetic resonance spectroscopy of the sensorimotor cortex and resting-state (RS) functional magnetic resonance imaging data were acquired before and after learning/stimulation. At the group level, neither learning nor anodal tDCS significantly modulated GABA levels or RS connectivity among task-relevant regions. However, changes in GABA levels from the baseline to post-learning session were significantly related to motor learning magnitude, age, and baseline GABA. Moreover, the change in functional connectivity between task-relevant regions, including bilateral motor cortices, was correlated with baseline GABA levels. These data collectively indicate that motor learning-related decreases in sensorimotor GABA levels and increases in functional connectivity are limited to those older adults with higher baseline GABA levels and who learn the most. Post-learning tDCS exerted no influence on GABA levels, functional connectivity or the relationships among these variables in older adults.

KW - aging

KW - functional connectivity

KW - functional neuroimaging

KW - gamma-aminobutyric acid

KW - motor learning

UR - http://www.scopus.com/inward/record.url?scp=85087217152&partnerID=8YFLogxK

U2 - 10.1002/hbm.25041

DO - 10.1002/hbm.25041

M3 - Article

C2 - 32583940

AN - SCOPUS:85087217152

VL - 41

SP - 3680

EP - 3695

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 13

ER -

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