Basic Pharmacokinetics of Substance Misuse

TY - CHAP

T1 - Basic Pharmacokinetics of Substance Misuse

AU - Wolff, Kim

PY - 2016

Y1 - 2016

N2 - Pharmacokinetics has been variously been defined as the study of the relationship between administered doses of a drug and the observed blood (plasma or serum) or tissue concentrations. It is a branch of pharmacology that explores what the body does to a drug and hence concerns itself with the quantitation of drug absorption, distribution, metabolism, and excretion (ADME) and more recently liberation (LADME).Despite the enormity of the pharmaceutical industry and the vast array of psychoactive substances available today for use, the mode of action of drugs in the body can be understood by reference to basic pharmacokinetic principals, assuming a linear relationship between blood and tissue (brain) exposure. Understanding the pharmacokinetic principles of a drug often explains the manner of its use and aids the clinician in a number of ways: in anticipating the optimal dosage regime, in predicting what may happen if the dosage regime is not followed, in responding to over dosing, and in monitoring the consequences of harmful or dependent use.

AB - Pharmacokinetics has been variously been defined as the study of the relationship between administered doses of a drug and the observed blood (plasma or serum) or tissue concentrations. It is a branch of pharmacology that explores what the body does to a drug and hence concerns itself with the quantitation of drug absorption, distribution, metabolism, and excretion (ADME) and more recently liberation (LADME).Despite the enormity of the pharmaceutical industry and the vast array of psychoactive substances available today for use, the mode of action of drugs in the body can be understood by reference to basic pharmacokinetic principals, assuming a linear relationship between blood and tissue (brain) exposure. Understanding the pharmacokinetic principles of a drug often explains the manner of its use and aids the clinician in a number of ways: in anticipating the optimal dosage regime, in predicting what may happen if the dosage regime is not followed, in responding to over dosing, and in monitoring the consequences of harmful or dependent use.

KW - ADDICTION

KW - PHARMACOKINETICS

KW - SUBSTANCE ABUSE

M3 - Chapter

SN - 978-1-14462-9867-1

SP - 37

EP - 56

BT - The SAGE Handbook of Drug and Alcohol Studies

A2 - Wolff, Kim

A2 - White, Jason

A2 - Karch, Steven

PB - Sage Publications

CY - London, UK

ER -