Bayesian Calibration of Electrophysiology Models Using Restitution Curve Emulators

Sam Coveney*, Cesare Corrado, Jeremy E. Oakley, Richard D. Wilkinson, Steven A. Niederer, Richard H. Clayton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Calibration of cardiac electrophysiology models is a fundamental aspect of model personalization for predicting the outcomes of cardiac therapies, simulation testing of device performance for a range of phenotypes, and for fundamental research into cardiac function. Restitution curves provide information on tissue function and can be measured using clinically feasible measurement protocols. We introduce novel “restitution curve emulators” as probabilistic models for performing model exploration, sensitivity analysis, and Bayesian calibration to noisy data. These emulators are built by decomposing restitution curves using principal component analysis and modeling the resulting coordinates with respect to model parameters using Gaussian processes. Restitution curve emulators can be used to study parameter identifiability via sensitivity analysis of restitution curve components and rapid inference of the posterior distribution of model parameters given noisy measurements. Posterior uncertainty about parameters is critical for making predictions from calibrated models, since many parameter settings can be consistent with measured data and yet produce very different model behaviors under conditions not effectively probed by the measurement protocols. Restitution curve emulators are therefore promising probabilistic tools for calibrating electrophysiology models.

Original languageEnglish
Article number693015
JournalFrontiers in Physiology
Volume12
Early online date22 Jul 2021
DOIs
Publication statusPublished - 22 Jul 2021

Keywords

  • Bayesian
  • calibration
  • cardiology
  • electrophysiology
  • emulation
  • Gaussian processes
  • restitution
  • sensitivity analysis

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