BDNF gene is a risk factor for schizophrenia in a Scottish population

M. Neves-Pereira; J. Cheung; A. Pasdar; F. Zhang; G. Breen; P. Yates; M. Sinclair; C. Crombie; N. Walker; D. M. St Clair

doi:10.1038/sj.mp.4001575

BDNF gene is a risk factor for schizophrenia in a Scottish population

M. Neves-Pereira, J. Cheung, A. Pasdar, F. Zhang, G. Breen, P. Yates, M. Sinclair, C. Crombie, N. Walker, D. M. St Clair

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Abstract

Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor ( BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar ( BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, which have been variously reported as associated with schizophrenia and BP. In our study, 321 probands with a primary diagnosis of schizophrenia or schizoaffective disorder, and 263 with a diagnosis of bipolar affective disorder, were examined together with 350 controls drawn from the same geographical region of Scotland. The val66met single-nucleotide polymorphism ( SNP) showed significant ( P = 0.005) association for valine ( allele G) with schizophrenia but not bipolar disorder. Haplotype analysis of val/ met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant ( P

Original language	English
Pages (from-to)	208 - 212
Number of pages	5
Journal	Molecular Psychiatry
Volume	10
Issue number	2
DOIs	https://doi.org/10.1038/sj.mp.4001575
Publication status	Published - Feb 2005

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abstract = "Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor ( BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar ( BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, which have been variously reported as associated with schizophrenia and BP. In our study, 321 probands with a primary diagnosis of schizophrenia or schizoaffective disorder, and 263 with a diagnosis of bipolar affective disorder, were examined together with 350 controls drawn from the same geographical region of Scotland. The val66met single-nucleotide polymorphism ( SNP) showed significant ( P = 0.005) association for valine ( allele G) with schizophrenia but not bipolar disorder. Haplotype analysis of val/ met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant ( P",

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AU - Neves-Pereira, M.

AU - Cheung, J.

AU - Pasdar, A.

AU - Zhang, F.

AU - Breen, G.

AU - Yates, P.

AU - Sinclair, M.

AU - Crombie, C.

AU - Walker, N.

AU - St Clair, D. M.

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AB - Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor ( BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar ( BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, which have been variously reported as associated with schizophrenia and BP. In our study, 321 probands with a primary diagnosis of schizophrenia or schizoaffective disorder, and 263 with a diagnosis of bipolar affective disorder, were examined together with 350 controls drawn from the same geographical region of Scotland. The val66met single-nucleotide polymorphism ( SNP) showed significant ( P = 0.005) association for valine ( allele G) with schizophrenia but not bipolar disorder. Haplotype analysis of val/ met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant ( P

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BDNF gene is a risk factor for schizophrenia in a Scottish population

Abstract

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