Behavioral interventions for antipsychotic induced appetite changes

TY - JOUR

T1 - Behavioral interventions for antipsychotic induced appetite changes

AU - Werneke, Ursula

AU - Taylor, David

AU - Sanders, Thomas A B

N1 - This article is part of the Topical Collection on Schizophrenia and Other Psychotic Disorders.

PY - 2013/3

Y1 - 2013/3

N2 - Weight gain remains a well recognized yet difficult to treat adverse effect of many anti-psychotic drugs including agents of the first and second generation. The weight gain liabilities of antipsychotic drugs are partly associated with their ability to increase appetite. Most behavioral interventions for weight control remain of limited efficacy, possibly because they do not specifically target the neuroendocrine factors regulating appetite. Identifying new weight management interventions directly acting on the biochemical and neuroendocrine mechanisms of anti-psychotic induced weight gain may help to improve the efficacy of behavioral weight management programs. Such potentially specific strategies include (1) using diets which do not increase appetite despite calorie restriction; (2) countering thirst as an anticholinergic side-effect; (3) discouraging cannabis use and (4) adding metformin to a behavioral intervention. In view of our currently rather limited treatment repertoire it seems timely systematically to explore such novel options.

AB - Weight gain remains a well recognized yet difficult to treat adverse effect of many anti-psychotic drugs including agents of the first and second generation. The weight gain liabilities of antipsychotic drugs are partly associated with their ability to increase appetite. Most behavioral interventions for weight control remain of limited efficacy, possibly because they do not specifically target the neuroendocrine factors regulating appetite. Identifying new weight management interventions directly acting on the biochemical and neuroendocrine mechanisms of anti-psychotic induced weight gain may help to improve the efficacy of behavioral weight management programs. Such potentially specific strategies include (1) using diets which do not increase appetite despite calorie restriction; (2) countering thirst as an anticholinergic side-effect; (3) discouraging cannabis use and (4) adding metformin to a behavioral intervention. In view of our currently rather limited treatment repertoire it seems timely systematically to explore such novel options.

U2 - 10.1007/s11920-012-0347-y

DO - 10.1007/s11920-012-0347-y

M3 - Article

C2 - 23404388

SN - 1523-3812

VL - 15

JO - CURRENT PSYCHIATRY REPORTS

JF - CURRENT PSYCHIATRY REPORTS

M1 - 347

ER -