Bench to bedside: Current advances in regenerative medicine

Gabriella Clarke; Peter Harley; Ella-Louise Hubber; Teodora Manea; Luigi Manuelli; Emily Read; Fiona M Watt

doi:10.1016/j.ceb.2018.05.006

Bench to bedside: Current advances in regenerative medicine

Gabriella Clarke, Peter Harley, Ella-Louise Hubber, Teodora Manea, Luigi Manuelli, Emily Read, Fiona M Watt

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

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Abstract

Regenerative medicine is a diverse and rapidly evolving field, employing core expertise from biologists, engineers, and clinicians. Recently the field has made significant progress towards regenerating or replacing tissues lost to age, disease or injury. Current strategies include transplantation of adult or pluripotent stem cells to replace tissue or support tissue healing. Promising approaches for the future of regenerative medicine include stimulating endogenous stem cells for in situ repair, transplantation of organoids to repair minor tissue injury, and the use of interspecies chimerism to produce functional metabolic organs for transplantation. In our review we focus on these emerging strategies, paying particular attention to their current and prospective translational impacts and challenges.

Original language	English
Pages (from-to)	59-66
Number of pages	8
Journal	Current Opinion in Cell Biology
Volume	55
Early online date	11 Jul 2018
DOIs	https://doi.org/10.1016/j.ceb.2018.05.006
Publication status	Published - Dec 2018

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10.1016/j.ceb.2018.05.006

Bench to bedside_CLARKE_Accepted9May2018_GREEN AAMAccepted author manuscript, 2.62 MBLicence: CC BY-NC-ND

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AU - Manuelli, Luigi

AU - Read, Emily

AU - Watt, Fiona M

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AB - Regenerative medicine is a diverse and rapidly evolving field, employing core expertise from biologists, engineers, and clinicians. Recently the field has made significant progress towards regenerating or replacing tissues lost to age, disease or injury. Current strategies include transplantation of adult or pluripotent stem cells to replace tissue or support tissue healing. Promising approaches for the future of regenerative medicine include stimulating endogenous stem cells for in situ repair, transplantation of organoids to repair minor tissue injury, and the use of interspecies chimerism to produce functional metabolic organs for transplantation. In our review we focus on these emerging strategies, paying particular attention to their current and prospective translational impacts and challenges.

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JO - Current Opinion in Cell Biology

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Bench to bedside: Current advances in regenerative medicine

Abstract

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