TY - JOUR
T1 - Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson’s disease
AU - EUROPAR, the IPMDS Non Motor P.D. Study Group
AU - Dafsari, Haidar S.
AU - Ray-Chaudhuri, Kallol
AU - Ashkan, Keyoumars
AU - Sachse, Lena
AU - Mahlstedt, Picabo
AU - Silverdale, Monty
AU - Rizos, Alexandra
AU - Strack, Marian
AU - Jost, Stefanie T.
AU - Reker, Paul
AU - Samuel, Michael
AU - Visser-Vandewalle, Veerle
AU - Evans, Julian
AU - Antonini, Angelo
AU - Martinez-Martin, Pablo
AU - Timmermann, Lars
AU - Ray-Chaudhuri, Kallol
AU - Schrag, Anette
AU - Weintraub, Daniel
AU - Barone, Paolo
AU - Brooks, David J.
AU - Brown, Richard G.
AU - Jenner, Peter
AU - Jeon, B.
AU - Lyons, Kelly
AU - Pavese, Nicola
AU - Politis, Marios
AU - Postuma, Ronald B.
AU - Schapira, Anthony
AU - Stocchi, Fabrizio
AU - Tsuboi, Yoshio
AU - Sauerbier, Anna
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Background: Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson’s disease (PD). However, the long-term effects of STN-DBS on sleep and its relationship with QoL outcome are unclear. Methods: In this prospective, observational, multicenter study including 73 PD patients undergoing bilateral STN-DBS, we examined PDSleep Scale (PDSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD-motor examination, -activities of daily living, and -complications (SCOPA-A, -B, -C), and levodopa-equivalent daily dose (LEDD) preoperatively, at 5 and 24 months follow-up. Longitudinal changes were analyzed with Friedman-tests or repeated-measures ANOVA, when parametric tests were applicable, and Bonferroni-correction for multiple comparisons. Post-hoc, visits were compared with Wilcoxon signed-rank/t-tests. The magnitude of clinical responses was investigated using effect size. Results: Significant beneficial effects of STN-DBS were observed for PDSS, PDQ-8, SCOPA-A, -B, and -C. All outcomes improved significantly at 5 months with subsequent decrements in gains at 24 months follow-up which were significant for PDSS, PDQ-8, and SCOPA-B. Comparing baseline and 24 months follow-up, we observed significant improvements of PDSS (small effect), SCOPA-A (moderate effect), -C, and LEDD (large effects). PDSS and PDQ-8 improvements correlated significantly at 5 and 24 months follow-up. Conclusions: In this multicenter study with a 24 months follow-up, we report significant sustained improvements after bilateral STN-DBS using a PD-specific sleep scale and a significant relationship between sleep and QoL improvements. This highlights the importance of sleep in holistic assessments of DBS outcomes.
AB - Background: Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson’s disease (PD). However, the long-term effects of STN-DBS on sleep and its relationship with QoL outcome are unclear. Methods: In this prospective, observational, multicenter study including 73 PD patients undergoing bilateral STN-DBS, we examined PDSleep Scale (PDSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD-motor examination, -activities of daily living, and -complications (SCOPA-A, -B, -C), and levodopa-equivalent daily dose (LEDD) preoperatively, at 5 and 24 months follow-up. Longitudinal changes were analyzed with Friedman-tests or repeated-measures ANOVA, when parametric tests were applicable, and Bonferroni-correction for multiple comparisons. Post-hoc, visits were compared with Wilcoxon signed-rank/t-tests. The magnitude of clinical responses was investigated using effect size. Results: Significant beneficial effects of STN-DBS were observed for PDSS, PDQ-8, SCOPA-A, -B, and -C. All outcomes improved significantly at 5 months with subsequent decrements in gains at 24 months follow-up which were significant for PDSS, PDQ-8, and SCOPA-B. Comparing baseline and 24 months follow-up, we observed significant improvements of PDSS (small effect), SCOPA-A (moderate effect), -C, and LEDD (large effects). PDSS and PDQ-8 improvements correlated significantly at 5 and 24 months follow-up. Conclusions: In this multicenter study with a 24 months follow-up, we report significant sustained improvements after bilateral STN-DBS using a PD-specific sleep scale and a significant relationship between sleep and QoL improvements. This highlights the importance of sleep in holistic assessments of DBS outcomes.
KW - Deep brain stimulation
KW - Non-motor symptoms
KW - Parkinson’s disease sleep scale
KW - Quality of life
KW - Subthalamic nucleus
UR - http://www.scopus.com/inward/record.url?scp=85081215296&partnerID=8YFLogxK
U2 - 10.1007/s00415-020-09743-1
DO - 10.1007/s00415-020-09743-1
M3 - Article
AN - SCOPUS:85081215296
SN - 0340-5354
VL - 267
SP - 1830
EP - 1841
JO - Journal of Neurology
JF - Journal of Neurology
IS - 6
ER -