King's College London

Research portal

Beyond Bacterial Killing: NADPH oxidase 2 is an immunomodulator

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)39-48
Number of pages10
JournalImmunology Letters
Accepted/In press20 Feb 2020
PublishedMay 2020

King's Authors


NADPH oxidase 2 is a superoxide-generating enzymatic complex based on the catalytic subunit gp91phox that is also known as Nox2. Initially identified in neutrophils, NADPH oxidase 2 was long considered responsible only for the killing of phagocytized microorganisms. However, advances in knowledge about redox signalling and the discovery of Nox2 expression in different cell types, including macrophages, endothelial cells (ECs), dendritic cells (DCs), B and T lymphocytes, have changed this paradigm. For instance, Nox2 expressed in macrophages and neutrophils limits the transcription of cytokines and toll-like receptors (TLRs) induced by lipopolysaccharide (LPS), whereas DC Nox2 facilitates antigen cross-presentation to T cells. More recently, our group observed that Nox2 inhibits the suppressive ability of regulatory T cells (Tregs) by limiting NF-κB and FoxP3 activation. In this review, we discuss non-canonical microbicidal functions and redox-signalling-associated roles of Nox2 in different cell types, emphasizing its roles in the innate and adaptive immune system.

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454