Biaryl polyamides as a new class of DNA quadruplex-binding ligands

TY - JOUR

T1 - Biaryl polyamides as a new class of DNA quadruplex-binding ligands

AU - Rahman, Khondaker

AU - Reszka, AP

AU - Gunaratnam, M

AU - Haider, SM

AU - Howard, PW

AU - Fox, KR

AU - Neidle, S

AU - Thurston, DE

PY - 2009/7/21

Y1 - 2009/7/21

N2 - We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA

AB - We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA

U2 - 10.1039/b902359c

DO - 10.1039/b902359c

M3 - Article

VL - 2009

SP - 4097

EP - 4099

JO - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

JF - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

IS - 27

M1 - N/A

ER -