Binucleine 2, an lsoform-Specific Inhibitor of Drosophila Aurora B Kinase, Provides Insights into the Mechanism of Cytokinesis

Yegor Smumyy; Angela V. Toms; Gilles R. Hickson; Michael J. Eck; Ulrike Eggert

doi:10.1021/cb1001685

Binucleine 2, an lsoform-Specific Inhibitor of Drosophila Aurora B Kinase, Provides Insights into the Mechanism of Cytokinesis

Yegor Smumyy, Angela V. Toms, Gilles R. Hickson, Michael J. Eck, Ulrike Eggert

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Aurora kinases are key regulators of cell division and important targets for cancer therapy. We report that Binuclelne 2 Is a highly isoform-specific Inhibitor of Drosophila Aurora B kinase, and we identify a single residue within the kinase active site that confers specificify for Aurora B. Using Binucleine 2, we show that Aurora B kinase activity is not required during. contractile ring Ingression, providing insight into the mechanism of cytokinesis.

Original language	English
Pages (from-to)	1015-1020
Number of pages	6
Journal	Acs Chemical Biology
Volume	5
Issue number	11
Early online date	30 Aug 2010
DOIs	https://doi.org/10.1021/cb1001685
Publication status	Published - Nov 2010

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title = "Binucleine 2, an lsoform-Specific Inhibitor of Drosophila Aurora B Kinase, Provides Insights into the Mechanism of Cytokinesis",

abstract = "Aurora kinases are key regulators of cell division and important targets for cancer therapy. We report that Binuclelne 2 Is a highly isoform-specific Inhibitor of Drosophila Aurora B kinase, and we identify a single residue within the kinase active site that confers specificify for Aurora B. Using Binucleine 2, we show that Aurora B kinase activity is not required during. contractile ring Ingression, providing insight into the mechanism of cytokinesis.",

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AU - Smumyy, Yegor

AU - Toms, Angela V.

AU - Hickson, Gilles R.

AU - Eck, Michael J.

AU - Eggert, Ulrike

PY - 2010/11

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N2 - Aurora kinases are key regulators of cell division and important targets for cancer therapy. We report that Binuclelne 2 Is a highly isoform-specific Inhibitor of Drosophila Aurora B kinase, and we identify a single residue within the kinase active site that confers specificify for Aurora B. Using Binucleine 2, we show that Aurora B kinase activity is not required during. contractile ring Ingression, providing insight into the mechanism of cytokinesis.

AB - Aurora kinases are key regulators of cell division and important targets for cancer therapy. We report that Binuclelne 2 Is a highly isoform-specific Inhibitor of Drosophila Aurora B kinase, and we identify a single residue within the kinase active site that confers specificify for Aurora B. Using Binucleine 2, we show that Aurora B kinase activity is not required during. contractile ring Ingression, providing insight into the mechanism of cytokinesis.

U2 - 10.1021/cb1001685

DO - 10.1021/cb1001685

M3 - Article

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JO - Acs Chemical Biology

JF - Acs Chemical Biology

IS - 11

ER -

Binucleine 2, an lsoform-Specific Inhibitor of Drosophila Aurora B Kinase, Provides Insights into the Mechanism of Cytokinesis

Abstract

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