Biocompatible inorganic nanoparticles for [F-18]-fluoride binding with applications in PET imaging

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


A wide selection of insoluble nanoparticulate metal salts was screened for avid binding of [F-18]-fluoride. Hydroxyapatite and aluminium hydroxide nanoparticles showed particularly avid and stable binding of [F-18]-fluoride in various biological media. The in vivo behaviour of the [F-18]-labelled hydroxyapatite and aluminium hydroxide particles was determined by PET-CT imaging in mice. [F-18]-labelled hydroxyapatite was stable in circulation and when trapped in various tissues (lung embolisation, subcutaneous and intramuscular), but accumulation in liver via reticuloendothelial clearance was followed by gradual degradation and release of [F-18]-fluoride (over a period of 4 h) which accumulated in bone. [F-18]-labelled aluminium hydroxide was also cleared to liver and spleen but degraded slightly even without liver uptake (subcutanenous and intramuscular). Both materials have properties that are an attractive basis for the design of molecular targeted PET imaging agents labelled with F-18.
Original languageEnglish
Pages (from-to)6226 - 6237
Number of pages12
Issue number23
Publication statusPublished - 21 Jun 2011


Dive into the research topics of 'Biocompatible inorganic nanoparticles for [F-18]-fluoride binding with applications in PET imaging'. Together they form a unique fingerprint.

Cite this