Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87 740 individuals

Jonathan Coleman; Julien Bryois; Helena A. Gaspar; Philip R Jansen; Jeanne E. Savage; Nathan Skene; Robert Plomin; Ana B. Muñoz-Manchado; Sten Linnarsson; Greg Crawford; Jens Hjerling-Leffler; Patrick F. Sullivan; Danielle Posthuma; Gerome Breen

doi:10.1038/s41380-018-0040-6

Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87 740 individuals

Jonathan Coleman, Julien Bryois, Helena A. Gaspar, Philip R Jansen, Jeanne E. Savage, Nathan Skene, Robert Plomin, Ana B. Muñoz-Manchado , Sten Linnarsson, Greg Crawford, Jens Hjerling-Leffler, Patrick F. Sullivan, Danielle Posthuma, Gerome Breen

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

316 Downloads (Pure)

Abstract

Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with brain tissue and single cell gene expression data to identify tissues and cell types associated with intelligence. GWAS data for IQ (N = 78 308) were meta-analyzed with a study comparing 1 247 individuals with mean IQ ~170 to 8 185 controls. Genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. Tissue-specific analyses find the most significant enrichment for frontal cortex brain expressed genes. These results suggest specific neuronal cell types and genes may be involved in intelligence and provide new hypotheses for neuroscience experiments using model systems.

Original language	English
Pages (from-to)	182–197
Journal	Molecular Psychiatry
Volume	24
Issue number	2
Early online date	8 Mar 2018
DOIs	https://doi.org/10.1038/s41380-018-0040-6
Publication status	Published - 1 Feb 2019

Access to Document

10.1038/s41380-018-0040-6

Biological annotation of genetic_COLEMAN_Accepted2January2018_GREEN AAMAccepted author manuscript, 300 KB

Cite this

Coleman, J., Bryois, J., Gaspar, H. A., Jansen, P. R., Savage, J. E., Skene, N., Plomin, R., Muñoz-Manchado , A. B., Linnarsson, S., Crawford, G., Hjerling-Leffler, J., Sullivan, P. F., Posthuma, D., & Breen, G. (2019). Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87 740 individuals. Molecular Psychiatry, 24(2), 182–197. https://doi.org/10.1038/s41380-018-0040-6

@article{f8c8829b7d4d4e5e89dace1ceecb1de7,

title = "Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87 740 individuals",

abstract = "Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with brain tissue and single cell gene expression data to identify tissues and cell types associated with intelligence. GWAS data for IQ (N = 78 308) were meta-analyzed with a study comparing 1 247 individuals with mean IQ ~170 to 8 185 controls. Genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. Tissue-specific analyses find the most significant enrichment for frontal cortex brain expressed genes. These results suggest specific neuronal cell types and genes may be involved in intelligence and provide new hypotheses for neuroscience experiments using model systems.",

author = "Jonathan Coleman and Julien Bryois and Gaspar, {Helena A.} and Jansen, {Philip R} and Savage, {Jeanne E.} and Nathan Skene and Robert Plomin and Mu{\~n}oz-Manchado, {Ana B.} and Sten Linnarsson and Greg Crawford and Jens Hjerling-Leffler and Sullivan, {Patrick F.} and Danielle Posthuma and Gerome Breen",

year = "2019",

month = feb,

day = "1",

doi = "10.1038/s41380-018-0040-6",

language = "English",

volume = "24",

pages = "182–197",

journal = "Molecular Psychiatry",

issn = "1359-4184",

publisher = "Springer Nature [academic journals on nature.com]",

number = "2",

}

Coleman, J, Bryois, J, Gaspar, HA, Jansen, PR, Savage, JE, Skene, N, Plomin, R, Muñoz-Manchado , AB, Linnarsson, S, Crawford, G, Hjerling-Leffler, J, Sullivan, PF, Posthuma, D & Breen, G 2019, 'Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87 740 individuals', Molecular Psychiatry, vol. 24, no. 2, pp. 182–197. https://doi.org/10.1038/s41380-018-0040-6

TY - JOUR

T1 - Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87 740 individuals

AU - Coleman, Jonathan

AU - Bryois, Julien

AU - Gaspar, Helena A.

AU - Jansen, Philip R

AU - Savage, Jeanne E.

AU - Skene, Nathan

AU - Plomin, Robert

AU - Muñoz-Manchado , Ana B.

AU - Linnarsson, Sten

AU - Crawford, Greg

AU - Hjerling-Leffler, Jens

AU - Sullivan, Patrick F.

AU - Posthuma, Danielle

AU - Breen, Gerome

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with brain tissue and single cell gene expression data to identify tissues and cell types associated with intelligence. GWAS data for IQ (N = 78 308) were meta-analyzed with a study comparing 1 247 individuals with mean IQ ~170 to 8 185 controls. Genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. Tissue-specific analyses find the most significant enrichment for frontal cortex brain expressed genes. These results suggest specific neuronal cell types and genes may be involved in intelligence and provide new hypotheses for neuroscience experiments using model systems.

AB - Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with brain tissue and single cell gene expression data to identify tissues and cell types associated with intelligence. GWAS data for IQ (N = 78 308) were meta-analyzed with a study comparing 1 247 individuals with mean IQ ~170 to 8 185 controls. Genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. Tissue-specific analyses find the most significant enrichment for frontal cortex brain expressed genes. These results suggest specific neuronal cell types and genes may be involved in intelligence and provide new hypotheses for neuroscience experiments using model systems.

U2 - 10.1038/s41380-018-0040-6

DO - 10.1038/s41380-018-0040-6

M3 - Article

SN - 1359-4184

VL - 24

SP - 182

EP - 197

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 2

ER -

Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87 740 individuals

Abstract

Access to Document

Fingerprint

Cite this