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Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states

Research output: Contribution to journalArticle

Maria Serena Longhi, Simon C. Robson, Steven H. Bernstein, Sara Serra, Silvia Deaglio

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalJournal of molecular medicine (Berlin, Germany)
Volume91
Issue number2
Early online date6 Jan 2013
DOIs
Publication statusPublished - Feb 2013

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Abstract

When present in the extracellular environment, the nucleoside adenosine protects cells and tissues from excessive inflammation and immune-mediated damage while promoting healing processes. This role has been highlighted experimentally using distinct disease models, including those of colitis, diabetes, asthma, sepsis, and ischemic injury. Adenosine also suppresses immune responses, as in the tumor microenvironment, assisting immune evasion while promoting angiogenesis. The mechanisms involved in adenosine signaling are addressed elsewhere in this issue. Here, the authors specifically address the generation of adenosine from extracellular nucleotides. This process is catalyzed by a series of plasma membrane ectonucleotidases, with the focus in this article on members of the CD39, CD73, and CD38 families and on their role in inflammatory and neoplastic hematological diseases. Pharmacological modulation of adenosine generation by drugs that either have or modulate ectonucleotidase function might be exploited to treat these diverse conditions.

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