Biomarkers for Congestion in Heart Failure: State-of-the-art and Future Directions

Antonio Luca Maria Parlati; Cristina Madaudo; Vincenzo Nuzzi; Paolo Manca; Piero Gentile; Daniela Di Lisi; Antonio Jordán-Ríos; Aamir Shamsi; Mattia Manzoni; Matthew Sadler; Cosmo Godino; Egle Corrado; Stefania Paolillo; Giuseppina Novo; Antonino Tuttolomondo; Alfredo Ruggero Galassi; Pasquale Perrone Filardi; Daniel Bromage; Antonio Cannata

doi:10.15420/cfr.2024.32

Biomarkers for Congestion in Heart Failure: State-of-the-art and Future Directions

Antonio Luca Maria Parlati, Cristina Madaudo^*, Vincenzo Nuzzi, Paolo Manca, Piero Gentile, Daniela Di Lisi, Antonio Jordán-Ríos, Aamir Shamsi, Mattia Manzoni, Matthew Sadler, Cosmo Godino, Egle Corrado, Stefania Paolillo, Giuseppina Novo, Antonino Tuttolomondo, Alfredo Ruggero Galassi, Pasquale Perrone Filardi, Daniel Bromage, Antonio Cannata

^*Corresponding author for this work

SCMMS Denmark Hill

Research output: Contribution to journal › Article › peer-review

Abstract

Congestion in patients with heart failure (HF) predicts adverse outcomes and is a leading cause of hospitalisation. Understanding congestion mechanisms helps in HF management and underscores the importance of tailored therapies to treat vascular and tissue congestion, improving patient outcomes. In this setting, several tools are available to detect congestion. Biomarker measurement is a simple, valid and affordable method to evaluate congestion in patients with HF. Natriuretic peptides are the most widely available tool in acute and chronic HF, helping diagnosis, risk stratification and management. Novel biomarkers can potentially become reliable allies in diagnosing and monitoring patients with HF.

Original language	English
Article number	e01
Journal	Cardiac failure review
Volume	11
DOIs	https://doi.org/10.15420/cfr.2024.32
Publication status	Published - 2025

Keywords

congestion
Heart failure
natriuretic peptides
novel biomarkers
troponin

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10.15420/cfr.2024.32

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Parlati, A. L. M., Madaudo, C., Nuzzi, V., Manca, P., Gentile, P., Di Lisi, D., Jordán-Ríos, A., Shamsi, A., Manzoni, M., Sadler, M., Godino, C., Corrado, E., Paolillo, S., Novo, G., Tuttolomondo, A., Galassi, A. R., Filardi, P. P., Bromage, D., & Cannata, A. (2025). Biomarkers for Congestion in Heart Failure: State-of-the-art and Future Directions. Cardiac failure review, 11, Article e01. https://doi.org/10.15420/cfr.2024.32

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title = "Biomarkers for Congestion in Heart Failure: State-of-the-art and Future Directions",

abstract = "Congestion in patients with heart failure (HF) predicts adverse outcomes and is a leading cause of hospitalisation. Understanding congestion mechanisms helps in HF management and underscores the importance of tailored therapies to treat vascular and tissue congestion, improving patient outcomes. In this setting, several tools are available to detect congestion. Biomarker measurement is a simple, valid and affordable method to evaluate congestion in patients with HF. Natriuretic peptides are the most widely available tool in acute and chronic HF, helping diagnosis, risk stratification and management. Novel biomarkers can potentially become reliable allies in diagnosing and monitoring patients with HF.",

keywords = "congestion, Heart failure, natriuretic peptides, novel biomarkers, troponin",

author = "Parlati, {Antonio Luca Maria} and Cristina Madaudo and Vincenzo Nuzzi and Paolo Manca and Piero Gentile and {Di Lisi}, Daniela and Antonio Jord{\'a}n-R{\'i}os and Aamir Shamsi and Mattia Manzoni and Matthew Sadler and Cosmo Godino and Egle Corrado and Stefania Paolillo and Giuseppina Novo and Antonino Tuttolomondo and Galassi, {Alfredo Ruggero} and Filardi, {Pasquale Perrone} and Daniel Bromage and Antonio Cannata",

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year = "2025",

doi = "10.15420/cfr.2024.32",

language = "English",

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journal = "Cardiac failure review",

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Parlati, ALM, Madaudo, C, Nuzzi, V, Manca, P, Gentile, P, Di Lisi, D, Jordán-Ríos, A, Shamsi, A, Manzoni, M, Sadler, M, Godino, C, Corrado, E, Paolillo, S, Novo, G, Tuttolomondo, A, Galassi, AR, Filardi, PP, Bromage, D & Cannata, A 2025, 'Biomarkers for Congestion in Heart Failure: State-of-the-art and Future Directions', Cardiac failure review, vol. 11, e01. https://doi.org/10.15420/cfr.2024.32

TY - JOUR

T1 - Biomarkers for Congestion in Heart Failure

T2 - State-of-the-art and Future Directions

AU - Parlati, Antonio Luca Maria

AU - Madaudo, Cristina

AU - Nuzzi, Vincenzo

AU - Manca, Paolo

AU - Gentile, Piero

AU - Di Lisi, Daniela

AU - Jordán-Ríos, Antonio

AU - Shamsi, Aamir

AU - Manzoni, Mattia

AU - Sadler, Matthew

AU - Godino, Cosmo

AU - Corrado, Egle

AU - Paolillo, Stefania

AU - Novo, Giuseppina

AU - Tuttolomondo, Antonino

AU - Galassi, Alfredo Ruggero

AU - Filardi, Pasquale Perrone

AU - Bromage, Daniel

AU - Cannata, Antonio

N1 - Publisher Copyright: © The Author(s) 2025. This work is open access and is licensed under CC BY-NC 4.0. Users may copy, redistribute and make derivative works for non‑commercial purposes, provided the original work is cited correctly.

PY - 2025

Y1 - 2025

N2 - Congestion in patients with heart failure (HF) predicts adverse outcomes and is a leading cause of hospitalisation. Understanding congestion mechanisms helps in HF management and underscores the importance of tailored therapies to treat vascular and tissue congestion, improving patient outcomes. In this setting, several tools are available to detect congestion. Biomarker measurement is a simple, valid and affordable method to evaluate congestion in patients with HF. Natriuretic peptides are the most widely available tool in acute and chronic HF, helping diagnosis, risk stratification and management. Novel biomarkers can potentially become reliable allies in diagnosing and monitoring patients with HF.

AB - Congestion in patients with heart failure (HF) predicts adverse outcomes and is a leading cause of hospitalisation. Understanding congestion mechanisms helps in HF management and underscores the importance of tailored therapies to treat vascular and tissue congestion, improving patient outcomes. In this setting, several tools are available to detect congestion. Biomarker measurement is a simple, valid and affordable method to evaluate congestion in patients with HF. Natriuretic peptides are the most widely available tool in acute and chronic HF, helping diagnosis, risk stratification and management. Novel biomarkers can potentially become reliable allies in diagnosing and monitoring patients with HF.

KW - congestion

KW - Heart failure

KW - natriuretic peptides

KW - novel biomarkers

KW - troponin

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DO - 10.15420/cfr.2024.32

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VL - 11

JO - Cardiac failure review

JF - Cardiac failure review

M1 - e01

ER -

Biomarkers for Congestion in Heart Failure: State-of-the-art and Future Directions

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Keywords

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