Biomarkers in Pediatric Liver Disease

Eirini Kyrana; Emer Catherine Fitzpatrick; Anil Dhawan

doi:10.1159/000436954

Biomarkers in Pediatric Liver Disease

King's College London

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

1 Citation (Scopus)

Abstract

The chronic nature of liver diseases in children and adults merits close follow-up for disease progression and/or treatment evaluation. Disease progression involves injury to liver cells resulting in cell death, varying degrees of inflammation, steatosis depending on the insult, oxidative stress, and eventually fibrosis and cirrhosis unless the process is modified with treatment or spontaneous recovery. Inflammation, cell death, and fibrosis are the three major processes that determine the outcome of liver disease irrespective of the etiology. Markers to measure the activity or status of these parameters in a dynamic way, particularly via noninvasive methods, are urgently required. In this chapter, we summarize recent advances in the identification of biomarkers of liver diseases: biomarkers corresponding to inflammation, cell death, fibrosis, and the development of malignancy.

Original language	English
Title of host publication	Next-Generation Nutritional Biomarkers to Guide Better Health Care
Publisher	Karger
Pages	49-58
Volume	84
DOIs	https://doi.org/10.1159/000436954
Publication status	E-pub ahead of print - 14 Jan 2016

Access to Document

10.1159/000436954

https://www.karger.com/Article/Abstract/436954

Cite this

@inbook{4a0793de481c496b8028d2ec1a7bfaef,

title = "Biomarkers in Pediatric Liver Disease",

abstract = "The chronic nature of liver diseases in children and adults merits close follow-up for disease progression and/or treatment evaluation. Disease progression involves injury to liver cells resulting in cell death, varying degrees of inflammation, steatosis depending on the insult, oxidative stress, and eventually fibrosis and cirrhosis unless the process is modified with treatment or spontaneous recovery. Inflammation, cell death, and fibrosis are the three major processes that determine the outcome of liver disease irrespective of the etiology. Markers to measure the activity or status of these parameters in a dynamic way, particularly via noninvasive methods, are urgently required. In this chapter, we summarize recent advances in the identification of biomarkers of liver diseases: biomarkers corresponding to inflammation, cell death, fibrosis, and the development of malignancy.",

author = "Eirini Kyrana and Fitzpatrick, \{Emer Catherine\} and Anil Dhawan",

year = "2016",

month = jan,

day = "14",

doi = "10.1159/000436954",

language = "English",

volume = "84",

pages = "49--58",

booktitle = "Next-Generation Nutritional Biomarkers to Guide Better Health Care",

publisher = "Karger",

}

TY - CHAP

T1 - Biomarkers in Pediatric Liver Disease

AU - Kyrana, Eirini

AU - Fitzpatrick, Emer Catherine

AU - Dhawan, Anil

PY - 2016/1/14

Y1 - 2016/1/14

N2 - The chronic nature of liver diseases in children and adults merits close follow-up for disease progression and/or treatment evaluation. Disease progression involves injury to liver cells resulting in cell death, varying degrees of inflammation, steatosis depending on the insult, oxidative stress, and eventually fibrosis and cirrhosis unless the process is modified with treatment or spontaneous recovery. Inflammation, cell death, and fibrosis are the three major processes that determine the outcome of liver disease irrespective of the etiology. Markers to measure the activity or status of these parameters in a dynamic way, particularly via noninvasive methods, are urgently required. In this chapter, we summarize recent advances in the identification of biomarkers of liver diseases: biomarkers corresponding to inflammation, cell death, fibrosis, and the development of malignancy.

AB - The chronic nature of liver diseases in children and adults merits close follow-up for disease progression and/or treatment evaluation. Disease progression involves injury to liver cells resulting in cell death, varying degrees of inflammation, steatosis depending on the insult, oxidative stress, and eventually fibrosis and cirrhosis unless the process is modified with treatment or spontaneous recovery. Inflammation, cell death, and fibrosis are the three major processes that determine the outcome of liver disease irrespective of the etiology. Markers to measure the activity or status of these parameters in a dynamic way, particularly via noninvasive methods, are urgently required. In this chapter, we summarize recent advances in the identification of biomarkers of liver diseases: biomarkers corresponding to inflammation, cell death, fibrosis, and the development of malignancy.

U2 - 10.1159/000436954

DO - 10.1159/000436954

M3 - Conference paper

VL - 84

SP - 49

EP - 58

BT - Next-Generation Nutritional Biomarkers to Guide Better Health Care

PB - Karger

ER -

Biomarkers in Pediatric Liver Disease

Abstract

Access to Document

Fingerprint

Cite this