Biomarkers of Berry Intake: Systematic Review Update

Hamza Mostafa; Alex Cheok; Tomás Meroño; Cristina Andres-Lacueva; Ana Rodriguez-Mateos

doi:10.1021/acs.jafc.3c01142

Biomarkers of Berry Intake: Systematic Review Update

Hamza Mostafa, Alex Cheok, Tomás Meroño, Cristina Andres-Lacueva, Ana Rodriguez-Mateos

Department of Nutrition, Food Sciences and Gastronomy, XaRTA, INSA-UB, School of Pharmacy and Food Sciences, Nutrition and Food Safety Research Institute, University of Barcelona, 08028 Barcelona, Spain.
Department of Nutritional Sciences
School of Life Course and Population Sciences
Faculty of Life Sciences and Medicine
1Department of Hepatology, Imperial College London, London, UK. 2Institute of Liver Studies at King's College School of Medicine at King's College Hospital, London, UK. 3Institute of Human Health and Performance, University College London, London, UK. 4Department of Asthma Allergy and Lung Biology, King's College London, London, UK. 5Division of Critical Care Medicine, University of Alberta, Edmonton, Canada.

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Abstract

Berries are rich in (poly)phenols, and these compounds may be beneficial to human health. Estimating berry consumption through self-reported questionnaires has been challenging due to compliance issues and a lack of precision. Estimation via food-derived biomarkers in biofluids was proposed as a complementary alternative. We aimed to review and update the existing evidence on biomarkers of intake for six different types of berries. A systematic literature search was performed to update a previous systematic review on PubMed, Web of Science, and Scopus from January 2020 until December 2022. Out of 42 papers, only 18 studies were eligible. A multimetabolite panel is suggested for blueberry and cranberry intake. Proposed biomarkers for blueberries include hippuric acid and malvidin glycosides. For cranberries, suggested biomarkers are glycosides of peonidin and cyanidin together with sulfate and glucuronide conjugates of phenyl-γ-valerolactone derivatives. No new metabolite candidates have been found for raspberries, strawberries, blackcurrants, and blackberries. Further studies are encouraged to validate these multimetabolite panels for improving the estimation of berry consumption.

Original language	English
Pages (from-to)	11789-11805
Number of pages	17
Journal	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume	71
Issue number	31
Early online date	27 Jul 2023
DOIs	https://doi.org/10.1021/acs.jafc.3c01142
Publication status	Published - 9 Aug 2023

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Cite this

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title = "Biomarkers of Berry Intake: Systematic Review Update",

abstract = "Berries are rich in (poly)phenols, and these compounds may be beneficial to human health. Estimating berry consumption through self-reported questionnaires has been challenging due to compliance issues and a lack of precision. Estimation via food-derived biomarkers in biofluids was proposed as a complementary alternative. We aimed to review and update the existing evidence on biomarkers of intake for six different types of berries. A systematic literature search was performed to update a previous systematic review on PubMed, Web of Science, and Scopus from January 2020 until December 2022. Out of 42 papers, only 18 studies were eligible. A multimetabolite panel is suggested for blueberry and cranberry intake. Proposed biomarkers for blueberries include hippuric acid and malvidin glycosides. For cranberries, suggested biomarkers are glycosides of peonidin and cyanidin together with sulfate and glucuronide conjugates of phenyl-γ-valerolactone derivatives. No new metabolite candidates have been found for raspberries, strawberries, blackcurrants, and blackberries. Further studies are encouraged to validate these multimetabolite panels for improving the estimation of berry consumption.",

author = "Hamza Mostafa and Alex Cheok and Tom{\'a}s Mero{\~n}o and Cristina Andres-Lacueva and Ana Rodriguez-Mateos",

note = "Funding Information: The study was supported by Grant PID2020–114921RB-C21 and PID2021–128542OA-I00 funded by MCIN/AEI/10.13039/501100011033 and CIBERFES, CB16/10/00269, from the Instituto de Salud Carlos III all of them by “ERDF A way of making Europe”, and La Marat{\'o} de TV-3 (553/C/2019). The Generalitat de Catalunya{\textquoteright}s Agency AGAUR of 2021SGR00687. Maria de Maeztu Unit of Excellence grant (CEX2021–001234-M) funded by (MICIN/AEI/FEDER, UE). CAL thanks ICREA Academia Award. HM thanks the scholarship and travel grants from the University of Barcelona (APIF) and Institut de Nutrici{\'o} i Seguretat Aliment{\`a}ria (INSA) de la Universitat de Barcelona, for the scholarship and travel grants. Funding Information: The study was supported by Grant PID2020-114921RB-C21 and PID2021-128542OA-I00 funded by MCIN/AEI/10.13039/501100011033 and CIBERFES, CB16/10/00269, from the Instituto de Salud Carlos III all of them by “ERDF A way of making Europe”, and La Marat{\'o} de TV-3 (553/C/2019). The Generalitat de Catalunya{\textquoteright}s Agency AGAUR of 2021SGR00687. Maria de Maeztu Unit of Excellence grant (CEX2021-001234-M) funded by (MICIN/AEI/FEDER, UE). CAL thanks ICREA Academia Award. HM thanks the scholarship and travel grants from the University of Barcelona (APIF) and Institut de Nutrici{\'o} i Seguretat Aliment{\`a}ria (INSA) de la Universitat de Barcelona, for the scholarship and travel grants Publisher Copyright: {\textcopyright} 2023 The Authors. Published by American Chemical Society.",

year = "2023",

month = aug,

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doi = "10.1021/acs.jafc.3c01142",

language = "English",

volume = "71",

pages = "11789--11805",

journal = "JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY",

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T1 - Biomarkers of Berry Intake

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AU - Mostafa, Hamza

AU - Cheok, Alex

AU - Meroño, Tomás

AU - Andres-Lacueva, Cristina

AU - Rodriguez-Mateos, Ana

N1 - Funding Information: The study was supported by Grant PID2020–114921RB-C21 and PID2021–128542OA-I00 funded by MCIN/AEI/10.13039/501100011033 and CIBERFES, CB16/10/00269, from the Instituto de Salud Carlos III all of them by “ERDF A way of making Europe”, and La Marató de TV-3 (553/C/2019). The Generalitat de Catalunya’s Agency AGAUR of 2021SGR00687. Maria de Maeztu Unit of Excellence grant (CEX2021–001234-M) funded by (MICIN/AEI/FEDER, UE). CAL thanks ICREA Academia Award. HM thanks the scholarship and travel grants from the University of Barcelona (APIF) and Institut de Nutrició i Seguretat Alimentària (INSA) de la Universitat de Barcelona, for the scholarship and travel grants. Funding Information: The study was supported by Grant PID2020-114921RB-C21 and PID2021-128542OA-I00 funded by MCIN/AEI/10.13039/501100011033 and CIBERFES, CB16/10/00269, from the Instituto de Salud Carlos III all of them by “ERDF A way of making Europe”, and La Marató de TV-3 (553/C/2019). The Generalitat de Catalunya’s Agency AGAUR of 2021SGR00687. Maria de Maeztu Unit of Excellence grant (CEX2021-001234-M) funded by (MICIN/AEI/FEDER, UE). CAL thanks ICREA Academia Award. HM thanks the scholarship and travel grants from the University of Barcelona (APIF) and Institut de Nutrició i Seguretat Alimentària (INSA) de la Universitat de Barcelona, for the scholarship and travel grants Publisher Copyright: © 2023 The Authors. Published by American Chemical Society.

PY - 2023/8/9

Y1 - 2023/8/9

N2 - Berries are rich in (poly)phenols, and these compounds may be beneficial to human health. Estimating berry consumption through self-reported questionnaires has been challenging due to compliance issues and a lack of precision. Estimation via food-derived biomarkers in biofluids was proposed as a complementary alternative. We aimed to review and update the existing evidence on biomarkers of intake for six different types of berries. A systematic literature search was performed to update a previous systematic review on PubMed, Web of Science, and Scopus from January 2020 until December 2022. Out of 42 papers, only 18 studies were eligible. A multimetabolite panel is suggested for blueberry and cranberry intake. Proposed biomarkers for blueberries include hippuric acid and malvidin glycosides. For cranberries, suggested biomarkers are glycosides of peonidin and cyanidin together with sulfate and glucuronide conjugates of phenyl-γ-valerolactone derivatives. No new metabolite candidates have been found for raspberries, strawberries, blackcurrants, and blackberries. Further studies are encouraged to validate these multimetabolite panels for improving the estimation of berry consumption.

AB - Berries are rich in (poly)phenols, and these compounds may be beneficial to human health. Estimating berry consumption through self-reported questionnaires has been challenging due to compliance issues and a lack of precision. Estimation via food-derived biomarkers in biofluids was proposed as a complementary alternative. We aimed to review and update the existing evidence on biomarkers of intake for six different types of berries. A systematic literature search was performed to update a previous systematic review on PubMed, Web of Science, and Scopus from January 2020 until December 2022. Out of 42 papers, only 18 studies were eligible. A multimetabolite panel is suggested for blueberry and cranberry intake. Proposed biomarkers for blueberries include hippuric acid and malvidin glycosides. For cranberries, suggested biomarkers are glycosides of peonidin and cyanidin together with sulfate and glucuronide conjugates of phenyl-γ-valerolactone derivatives. No new metabolite candidates have been found for raspberries, strawberries, blackcurrants, and blackberries. Further studies are encouraged to validate these multimetabolite panels for improving the estimation of berry consumption.

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U2 - 10.1021/acs.jafc.3c01142

DO - 10.1021/acs.jafc.3c01142

M3 - Review article

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SN - 0021-8561

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JO - JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

JF - JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

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ER -

Biomarkers of Berry Intake: Systematic Review Update

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