Biomechanical simulation of atrophy in MR images

M Sonka (Editor), William Crum, D L G Hill, N A Thacker, P A Bromiley

Research output: Chapter in Book/Report/Conference proceedingConference paper

13 Citations (Scopus)


Progressive cerebral atrophy is a physical component of the most common forms of dementia - Alzheimer's disease, vascular dementia, Lewy-Body disease and fronto-temporal dementia. We propose a phenomenological simulation of atrophy in MR images that provides gold-standard data; the origin and rate of progression of atrophy can be controlled and the resultant remodelling of brain structures is known. We simulate diffuse global atrophic change by generating global volumetric change in a physically realistic biomechanical model of the human brain. Thermal loads are applied to either single, or multiple, tissue types within the brain to drive tissue expansion or contraction. Mechanical readjustment is modelled using finite element methods (FEM). In this preliminary work we apply these techniques to the MNI brainweb phantom to produce new images exhibiting global diffuse atrophy. We compare the applied atrophy with that measured from the images using an established quantitative technique. Early results are encouraging and suggest that the model can be extended and used for validation of atrophy measurement techniques and non-rigid image registration, and for understanding the effect of atrophy on brain shape.
Original languageEnglish
Title of host publicationP SOC PHOTO-OPT INSTRUM ENG
Place of PublicationBELLINGHAM
PublisherSpie-Int Society Optical Engineering
Pages481 - 490
Number of pages10
ISBN (Print)0-8194-4833-8
Publication statusPublished - 2003
EventMedical Imaging 2003 Conference - SAN DIEGO, CALIFORNIA
Duration: 1 Jan 2003 → …

Publication series



ConferenceMedical Imaging 2003 Conference
Period1/01/2003 → …


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