Biomedical Research in the 21st Century: Multiple Challenges in Resolving Reproducibility Issues

TY - CHAP

T1 - Biomedical Research in the 21st Century

T2 - Multiple Challenges in Resolving Reproducibility Issues

AU - Mullane, Kevin

AU - Curtis, Michael J.

AU - Williams, Michael

PY - 2017/10/10

Y1 - 2017/10/10

N2 - The documented lack of reproducibility in biomedical research directly impacts the value and output of drug discovery disciplines like pharmacology that are integral for understanding disease pathophysiology, the discovery of drug targets, and the development of new drug candidates. This chapter discusses the reproducibility issue in the context of the challenges facing the biopharmaceutical industry in the 21st century. These include drug costs and productivity; the perceived impact of the biotechnology revolution and newer disruptive technology initiatives from Silicon Valley companies. These issues are placed in the context of the systemic flaws and perverse career incentives that characterize the current biomedical research culture, the unintended consequences from which appear to sufficient consequences to change behaviors that result in bad science. This emphasizes the need for the biomedical research community to proactively improve reproducibility via initiatives like the recent AAM Framework for Improving the Quality of Research.

AB - The documented lack of reproducibility in biomedical research directly impacts the value and output of drug discovery disciplines like pharmacology that are integral for understanding disease pathophysiology, the discovery of drug targets, and the development of new drug candidates. This chapter discusses the reproducibility issue in the context of the challenges facing the biopharmaceutical industry in the 21st century. These include drug costs and productivity; the perceived impact of the biotechnology revolution and newer disruptive technology initiatives from Silicon Valley companies. These issues are placed in the context of the systemic flaws and perverse career incentives that characterize the current biomedical research culture, the unintended consequences from which appear to sufficient consequences to change behaviors that result in bad science. This emphasizes the need for the biomedical research community to proactively improve reproducibility via initiatives like the recent AAM Framework for Improving the Quality of Research.

KW - Biomedical research culture

KW - Drug discovery

KW - Drug prices

KW - Healthcare

UR - http://www.scopus.com/inward/record.url?scp=85048999969&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-804725-5.00006-9

DO - 10.1016/B978-0-12-804725-5.00006-9

M3 - Chapter

SN - 9780128047255

SP - 307

EP - 353

BT - Research in the Biomedical Sciences

PB - Elsevier

ER -