Biophysical analysis of cancer stem cell-potent copper(ii) coordination complexes

TY - JOUR

T1 - Biophysical analysis of cancer stem cell-potent copper(ii) coordination complexes

AU - Zheng, Puyi

AU - Eskandari, Arvin

AU - Lu, Chunxin

AU - Laws, Kristine

AU - Aldous, Leigh

AU - Suntharalingam, Kogularamanan

PY - 2019/5/7

Y1 - 2019/5/7

N2 - Copper(ii) coordination complexes, 1 and 2, containing nonsteroidal anti-inflammatory drugs (NSAIDs) potently kill breast cancer stem cells (CSCs) and bulk breast cancer cells. Although detailed biological studies have been conducted to shed light on their mechanism of cytotoxicity, little is known about their molecular level mechanism of action. This biophysical study, aided by the preparation of a fluorophore-containing analogue, 3, reveals that the complexes operate by undergoing reduction to a copper(i) form and releasing the associated NSAIDs.

AB - Copper(ii) coordination complexes, 1 and 2, containing nonsteroidal anti-inflammatory drugs (NSAIDs) potently kill breast cancer stem cells (CSCs) and bulk breast cancer cells. Although detailed biological studies have been conducted to shed light on their mechanism of cytotoxicity, little is known about their molecular level mechanism of action. This biophysical study, aided by the preparation of a fluorophore-containing analogue, 3, reveals that the complexes operate by undergoing reduction to a copper(i) form and releasing the associated NSAIDs.

UR - http://www.scopus.com/inward/record.url?scp=85060679379&partnerID=8YFLogxK

U2 - 10.1039/c8dt04706e

DO - 10.1039/c8dt04706e

M3 - Article

C2 - 30632590

AN - SCOPUS:85060679379

SN - 1477-9226

VL - 48

SP - 5892

EP - 5896

JO - Dalton Transactions

JF - Dalton Transactions

IS - 18

ER -