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Biophysical analysis of cancer stem cell-potent copper(ii) coordination complexes

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)5892-5896
Number of pages5
JournalDalton Transactions
Volume48
Issue number18
Early online date2 Jan 2019
DOIs
Accepted/In press2 Jan 2019
E-pub ahead of print2 Jan 2019
Published7 May 2019

King's Authors

Abstract

Copper(ii) coordination complexes, 1 and 2, containing nonsteroidal anti-inflammatory drugs (NSAIDs) potently kill breast cancer stem cells (CSCs) and bulk breast cancer cells. Although detailed biological studies have been conducted to shed light on their mechanism of cytotoxicity, little is known about their molecular level mechanism of action. This biophysical study, aided by the preparation of a fluorophore-containing analogue, 3, reveals that the complexes operate by undergoing reduction to a copper(i) form and releasing the associated NSAIDs.

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