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Biophysical Modeling to Determine the Optimization of Left Ventricular Pacing Site and AV/VV Delays in the Acute and Chronic Phase of Cardiac Resynchronization Therapy

Research output: Contribution to journalArticle

Original languageEnglish
JournalJournal of Cardiovascular Electrophysiology
Early online date25 Nov 2016
Publication statusE-pub ahead of print - 25 Nov 2016


  • JCE_160710.R2.pdf

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King's Authors


Device Optimization for Acute and Chronic CRT: Background: Cardiac anatomy and function adapt in response to chronic cardiac resynchronization therapy (CRT). The effects of these changes on the optimal left ventricle (LV) lead location and timing delay settings have yet to be fully explored. Objective: To predict the effects of chronic CRT on the optimal LV lead location and device timing settings over time. Methods: Biophysical computational cardiac models were generated for 3 patients, immediately post-implant (ACUTE) and after at least 6 months of CRT (CHRONIC). Optimal LV pacing area and device settings were predicted by pacing the ACUTE and CHRONIC models across the LV epicardium (49 sites each) with a range of 9 pacing settings and simulating the acute hemodynamic response (AHR) of the heart. Results: There were statistically significant differences between the distribution of the AHR in the ACUTE and CHRONIC models (P <0.0005 in all cases). The site delivering the maximal AHR shifted location between the ACUTE and CHRONIC models but provided a negligible improvement (

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