BiP regulates autoimmune inflammation and tissue damage

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


The endoplasmic reticulum chaperone BiP, in addition to its many important intracellular functions, has anti-inflammatory and immunomodulatory properties when present in the extracellular environment by the stimulation of an anti-inflammatory gene programme from human monocytes and by the development of T-cells that secrete regulatory cytokines such as interleukin-10 and interleukin-4. It can both prevent as well as treat ongoing collagen-induced arthritis. It is, therefore, a potential new biologic therapy for rheumatoid arthritis. (c) 2005 Elsevier B.V. All rights reserved
Original languageEnglish
Pages (from-to)140 - 142
Number of pages3
Issue number2
Publication statusPublished - Feb 2006


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