BiP regulates autoimmune inflammation and tissue damage

G S Panayi; V M Corrigall

doi:10.1016/j.autrev.2005.08.006

BiP regulates autoimmune inflammation and tissue damage

G S Panayi, V M Corrigall

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The endoplasmic reticulum chaperone BiP, in addition to its many important intracellular functions, has anti-inflammatory and immunomodulatory properties when present in the extracellular environment by the stimulation of an anti-inflammatory gene programme from human monocytes and by the development of T-cells that secrete regulatory cytokines such as interleukin-10 and interleukin-4. It can both prevent as well as treat ongoing collagen-induced arthritis. It is, therefore, a potential new biologic therapy for rheumatoid arthritis. (c) 2005 Elsevier B.V. All rights reserved

Original language	English
Pages (from-to)	140 - 142
Number of pages	3
Journal	AUTOIMMUNITY REVIEWS
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/j.autrev.2005.08.006
Publication status	Published - Feb 2006

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title = "BiP regulates autoimmune inflammation and tissue damage",

abstract = "The endoplasmic reticulum chaperone BiP, in addition to its many important intracellular functions, has anti-inflammatory and immunomodulatory properties when present in the extracellular environment by the stimulation of an anti-inflammatory gene programme from human monocytes and by the development of T-cells that secrete regulatory cytokines such as interleukin-10 and interleukin-4. It can both prevent as well as treat ongoing collagen-induced arthritis. It is, therefore, a potential new biologic therapy for rheumatoid arthritis. (c) 2005 Elsevier B.V. All rights reserved",

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AB - The endoplasmic reticulum chaperone BiP, in addition to its many important intracellular functions, has anti-inflammatory and immunomodulatory properties when present in the extracellular environment by the stimulation of an anti-inflammatory gene programme from human monocytes and by the development of T-cells that secrete regulatory cytokines such as interleukin-10 and interleukin-4. It can both prevent as well as treat ongoing collagen-induced arthritis. It is, therefore, a potential new biologic therapy for rheumatoid arthritis. (c) 2005 Elsevier B.V. All rights reserved

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BiP regulates autoimmune inflammation and tissue damage

Abstract

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