Birth Weight was longitudinally associated with Cardiometabolic Risk Markers in Mid-Adulthood

Fawaz Mzayek, J Kennedy Cruickshank, Doris Amoah, Sathanur Srinivasan, Wei Chen, Gerald S. Berenson

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)
134 Downloads (Pure)

Abstract

Purpose

Birth weight (BW) is associated with risk of cardiovascular (CV) disease. The findings form studies examined the association of BW with metabolic markers of CV risk were inconsistent and controversial. We examined the association of BW with insulin resistance and blood lipids using repeated measures up to mid-adulthood.

Methods

Data from seven screenings of the Bogalusa Heart Study—a longitudinal study of cardiovascular risk factors in Bogalusa, LA, are analyzed using generalized estimation equations method. Participants with birth data and at least one measurement of study outcomes between 18-44 years of age (n=2,034) were included.

Results

BW is inversely associated with insulin resistance, triglycerides and total cholesterol (P<0.01 for all). For 1-kg decrease in BW, insulin resistance increased by 2.3 units, 95% CI = 0.7, 3.9; triglycerides by 8.7 mg/dL, 95% CI = 4.9, 12.4 and total cholesterol by 5.4 mg/dL, 95% CI = 1.8, 9.1. The association of body mass with adult blood lipids levels is weaker in persons with low- vs. normal BW.

Conclusions

The study provides strong evidence of an inverse relationship of BW with adulthood cardiometabolic risk profile. Persons born with low BW are maybe less responsive to preventive interventions aiming at weight reduction.

Original languageEnglish
Pages (from-to)643–647
JournalAnnals of Epidemiology
Volume26
Issue number9
Early online date10 Aug 2016
DOIs
Publication statusPublished - Sept 2016

Keywords

  • Birth weight
  • cardiovascular risk
  • cholesterol
  • insulin resistance
  • HOMA-IR
  • lipids
  • triglycerides

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