Birthweight and the risk of atopic diseases: The ISAAC Phase III study

Edwin A. Mitchell; Tadd Clayton; Luis García-Marcos; Neil Pearce; Sunia Foliaki; Gary Wong; N. Aït-Khaled; H. R. Anderson; M. I. Asher; R. Beasley; B. Björkstén; B. Brunekreef; J. Crane; P. Ellwood; C. Flohr; F. Forastiere; U. Keil; C. K.W. Lai; J. Mallol; S. Montefort; J. Odhiambo; C. F. Robertson; A. W. Stewart; D. Strachan; E. von Mutius; S. K. Weiland; G. Weinmayr; H. Williams; E. Ellwood; L. de Freitas Souza; D. Rennie; P. Aguilar; L. Amarales; G. Aristizábal; A. M. Cepeda; M. A. Riikjärv; G. Zsigmond; S. N. Mantri; A. V. Pherwani; S. Rego; S. Salvi; S. K. Sharma; T. U. Sukumaran; P. S. Suresh Babu; C. B. Kartasasmita; C. Moyes; C. Nunes; H. B. Lee; J. L. Huang; C. C. Kao

doi:10.1111/pai.12210

Birthweight and the risk of atopic diseases: The ISAAC Phase III study

Edwin A. Mitchell^*
, Tadd Clayton
, Luis García-Marcos
, Neil Pearce
, Sunia Foliaki
, Gary Wong
, N. Aït-Khaled
, H. R. Anderson
, M. I. Asher
, R. Beasley
, B. Björkstén
, B. Brunekreef
, J. Crane
, P. Ellwood
, C. Flohr
, F. Forastiere
, U. Keil
, C. K.W. Lai
, J. Mallol
, S. Montefort

J. Odhiambo, C. F. Robertson, A. W. Stewart, D. Strachan, E. von Mutius, S. K. Weiland, G. Weinmayr, H. Williams, E. Ellwood, L. de Freitas Souza, D. Rennie, P. Aguilar, L. Amarales, G. Aristizábal, A. M. Cepeda, M. A. Riikjärv, G. Zsigmond, S. N. Mantri, A. V. Pherwani, S. Rego, S. Salvi, S. K. Sharma, T. U. Sukumaran, P. S. Suresh Babu, C. B. Kartasasmita, C. Moyes, C. Nunes, H. B. Lee, J. L. Huang, C. C. Kao

^*Corresponding author for this work

Faculty of Medical and Health Sciences
Department of Paediatrics, University of Otago Christchurch, Christchurch, New Zealand
Child and Youth Health
Hospital Clínico Universitario Virgen de la Arrixaca
LSHTM London School of Hygiene and Tropical Medicine
Massey University
Prince of Wales Hospital Hong Kong
International Union Against Tuberculosis and Lung Disease
St George's, University of London
Medical Research Institute of New Zealand
Karolinska Institute
Utrecht University
University of Otago Medical School
Department of Paediatric Allergy and Dermatology
St John's Institute of Dermatology
Local Health Authority
Institut für Kernphysik
Chinese University of Hong Kong
University of Santiago
University of Malta
Kenya Medical Research Institute
Murdoch Childrens Res Ctr, Murdoch Children's Research Institute
Ludwig Maximilian University of Munich
University of Ulm
Nottingham University Hospitals NHS Trust

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.

Original language	English
Pages (from-to)	264-270
Number of pages	7
Journal	Pediatric Allergy and Immunology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1111/pai.12210
Publication status	Published - 1 May 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Asthma
Eczema
ISAAC
Low birthweight
Rhinoconjunctivitis
Risk factors

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10.1111/pai.12210

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Mitchell, E. A., Clayton, T., García-Marcos, L., Pearce, N., Foliaki, S., Wong, G., Aït-Khaled, N., Anderson, H. R., Asher, M. I., Beasley, R., Björkstén, B., Brunekreef, B., Crane, J., Ellwood, P., Flohr, C., Forastiere, F., Keil, U., Lai, C. K. W., Mallol, J., ... Kao, C. C. (2014). Birthweight and the risk of atopic diseases: The ISAAC Phase III study. Pediatric Allergy and Immunology, 25(3), 264-270. https://doi.org/10.1111/pai.12210

@article{26f8a5e4edcd4039bf280fcdc56acc0f,

title = "Birthweight and the risk of atopic diseases: The ISAAC Phase III study",

abstract = "Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95\% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.",

keywords = "Asthma, Eczema, ISAAC, Low birthweight, Rhinoconjunctivitis, Risk factors",

author = "Mitchell, \{Edwin A.\} and Tadd Clayton and Luis Garc{\'i}a-Marcos and Neil Pearce and Sunia Foliaki and Gary Wong and N. A{\"i}t-Khaled and Anderson, \{H. R.\} and Asher, \{M. I.\} and R. Beasley and B. Bj{\"o}rkst{\'e}n and B. Brunekreef and J. Crane and P. Ellwood and C. Flohr and F. Forastiere and U. Keil and Lai, \{C. K.W.\} and J. Mallol and S. Montefort and J. Odhiambo and Robertson, \{C. F.\} and Stewart, \{A. W.\} and D. Strachan and \{von Mutius\}, E. and Weiland, \{S. K.\} and G. Weinmayr and H. Williams and E. Ellwood and \{de Freitas Souza\}, L. and D. Rennie and P. Aguilar and L. Amarales and G. Aristiz{\'a}bal and Cepeda, \{A. M.\} and Riikj{\"a}rv, \{M. A.\} and G. Zsigmond and Mantri, \{S. N.\} and Pherwani, \{A. V.\} and S. Rego and S. Salvi and Sharma, \{S. K.\} and Sukumaran, \{T. U.\} and \{Suresh Babu\}, \{P. S.\} and Kartasasmita, \{C. B.\} and C. Moyes and C. Nunes and Lee, \{H. B.\} and Huang, \{J. L.\} and Kao, \{C. C.\}",

year = "2014",

month = may,

day = "1",

doi = "10.1111/pai.12210",

language = "English",

volume = "25",

pages = "264--270",

journal = "Pediatric Allergy and Immunology",

issn = "0905-6157",

publisher = "Blackwell Munksgaard",

number = "3",

}

Mitchell, EA, Clayton, T, García-Marcos, L, Pearce, N, Foliaki, S, Wong, G, Aït-Khaled, N, Anderson, HR, Asher, MI, Beasley, R, Björkstén, B, Brunekreef, B, Crane, J, Ellwood, P, Flohr, C, Forastiere, F, Keil, U, Lai, CKW, Mallol, J, Montefort, S, Odhiambo, J, Robertson, CF, Stewart, AW, Strachan, D, von Mutius, E, Weiland, SK, Weinmayr, G, Williams, H, Ellwood, E, de Freitas Souza, L, Rennie, D, Aguilar, P, Amarales, L, Aristizábal, G, Cepeda, AM, Riikjärv, MA, Zsigmond, G, Mantri, SN, Pherwani, AV, Rego, S, Salvi, S, Sharma, SK, Sukumaran, TU, Suresh Babu, PS, Kartasasmita, CB, Moyes, C, Nunes, C, Lee, HB, Huang, JL & Kao, CC 2014, 'Birthweight and the risk of atopic diseases: The ISAAC Phase III study', Pediatric Allergy and Immunology, vol. 25, no. 3, pp. 264-270. https://doi.org/10.1111/pai.12210

TY - JOUR

T1 - Birthweight and the risk of atopic diseases

T2 - The ISAAC Phase III study

AU - Mitchell, Edwin A.

AU - Clayton, Tadd

AU - García-Marcos, Luis

AU - Pearce, Neil

AU - Foliaki, Sunia

AU - Wong, Gary

AU - Aït-Khaled, N.

AU - Anderson, H. R.

AU - Asher, M. I.

AU - Beasley, R.

AU - Björkstén, B.

AU - Brunekreef, B.

AU - Crane, J.

AU - Ellwood, P.

AU - Flohr, C.

AU - Forastiere, F.

AU - Keil, U.

AU - Lai, C. K.W.

AU - Mallol, J.

AU - Montefort, S.

AU - Odhiambo, J.

AU - Robertson, C. F.

AU - Stewart, A. W.

AU - Strachan, D.

AU - von Mutius, E.

AU - Weiland, S. K.

AU - Weinmayr, G.

AU - Williams, H.

AU - Ellwood, E.

AU - de Freitas Souza, L.

AU - Rennie, D.

AU - Aguilar, P.

AU - Amarales, L.

AU - Aristizábal, G.

AU - Cepeda, A. M.

AU - Riikjärv, M. A.

AU - Zsigmond, G.

AU - Mantri, S. N.

AU - Pherwani, A. V.

AU - Rego, S.

AU - Salvi, S.

AU - Sharma, S. K.

AU - Sukumaran, T. U.

AU - Suresh Babu, P. S.

AU - Kartasasmita, C. B.

AU - Moyes, C.

AU - Nunes, C.

AU - Lee, H. B.

AU - Huang, J. L.

AU - Kao, C. C.

PY - 2014/5/1

Y1 - 2014/5/1

N2 - Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.

AB - Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.

KW - Asthma

KW - Eczema

KW - ISAAC

KW - Low birthweight

KW - Rhinoconjunctivitis

KW - Risk factors

UR - https://www.scopus.com/pages/publications/84898833349

U2 - 10.1111/pai.12210

DO - 10.1111/pai.12210

M3 - Article

C2 - 24750571

AN - SCOPUS:84898833349

SN - 0905-6157

VL - 25

SP - 264

EP - 270

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

IS - 3

ER -

Birthweight and the risk of atopic diseases: The ISAAC Phase III study

Abstract

UN SDGs

Keywords

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