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Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia

Research output: Contribution to journalArticle

Hannah Meiklejohn, Md Shaki Mostaid, Sandra Luza, Serafino G. Mancuso, Dali Kang, Sonny Atherton, Debora A. Rothmond, Cynthia Shannon Weickert, Carlos M. Opazo, Christos Pantelis, Ashley I. Bush, Ian P. Everall, Chad A. Bousman

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalJournal of psychiatric research
Volume113
Early online date8 Mar 2019
DOIs
Publication statusPublished - 1 Jun 2019

King's Authors

Abstract

A number of recent studies have suggested the ubiquitin proteasome system (UPS) in schizophrenia is dysfunctional. The purpose of this study was to investigate UBE2K, a ubiquitin-conjugating (E2) enzyme within the UPS that has been associated with psychosis symptom severity, in the blood and brain of individuals with schizophrenia. Whole blood and erythrocytes from 128 (71 treatment-resistant schizophrenia, 57 healthy controls) individuals as well as frozen dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) post-mortem samples from 74 (37 schizophrenia, 37 controls) individuals were obtained. UBE2K gene expression was assayed in whole blood and DLPFC samples, whereas protein levels were assayed in erythrocytes and OFC samples. Elevated levels of UBE2K mRNA were observed in whole blood of individuals with schizophrenia (p = 0.03) but not in the DLPFC, while protein levels were raised in erythrocytes and the OFC (p 

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